Interstrand crosslinked nucleic acids offer diverse applications in DNA nanotechnology, therapeutics, and biochemistry, yet efficient crosslinking strategies remain underexplored. Here, the authors incorporate two proximal 2′-deoxythioguanosine residues within oligo DNA duplexes for efficient disulfide crosslinking under chemical oxidation and photoinduced reaction.
- Jamila Abbas Osman
- Kazumitsu Onizuka
- Fumi Nagatsugi
