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Showing 1–17 of 17 results
Advanced filters: Author: Jan Lammerding Clear advanced filters

  • Amiad Pavlov, Heffler, et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target.

    • Daria Amiad Pavlov
    • Julie Heffler
    • Benjamin Prosser
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1501-1520

  • Lamin mutations responsible for muscular dystrophy are shown to reduce nuclear envelope stability, resulting in mechanically induced nuclear envelope rupture, DNA damage and activation of DNA damage response pathways that lead to muscle cell death. Preventing nuclear envelope damage by reducing cytoskeletal forces on the nucleus improves muscle fibre health and function.

    • Ashley J. Earle
    • Tyler J. Kirby
    • Jan Lammerding
    Research
    Nature Materials
    Volume: 19, P: 464-473

  • A nanoscale polymer layer formed by mucins at the surface of tumour cells protects them against immune cell attack. This shield can be circumvented through immune cell engineering, using chimeric antigen receptors to stimulate natural killer and T cells or by tethering glycocalyx-editing enzymes to immune cells.

    • Sangwoo Park
    • Marshall J. Colville
    • Matthew J. Paszek
    Research
    Nature Materials
    Volume: 23, P: 429-438

  • Forces applied to the cell surface induce stretching of the chromatin in the nucleus and a rapid increase in gene expression.

    • Tyler J. Kirby
    • Jan Lammerding
    News & Views
    Nature Materials
    Volume: 15, P: 1227-1229

  • Ultrack leverages candidate segmentations from multiple algorithms and temporal consistency across time points for robust, long-term 3D segmentation in challenging samples such as densely packed zebrafish, fruit fly and nematode embryos.

    • Jordão Bragantini
    • Ilan Theodoro
    • Loïc A. Royer
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 2423-2436

  • Mechanical forces influence both cytoplasmic and nuclear events. Kirby and Lammerding discuss recent evidence suggesting that the nucleus itself is a mechanosensor and methods to study nuclear mechanotransduction.

    • Tyler J. Kirby
    • Jan Lammerding
    Reviews
    Nature Cell Biology
    Volume: 20, P: 373-381

  • Mesenchymal stromal cells with their nuclei removed by density-gradient centrifugation and displaying chemoattractant receptors and endothelial-cell-binding molecules function as effective vehicles for the delivery of therapeutics to diseased tissue.

    • Huawei Wang
    • Christina N. Alarcón
    • Richard L. Klemke
    Research
    Nature Biomedical Engineering
    Volume: 6, P: 882-897

  • Cells sense their physical surroundings by translating mechanical forces and deformations into biochemical signals. Defects in mechanotransduction are implicated in the development of many diseases, ranging from muscular dystrophies, cardiomyopathies and loss of hearing to cancer progression and metastasis.

    • Diana E. Jaalouk
    • Jan Lammerding
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 63-73

  • Fluorescent aptamers covalently bound to the membrane of mesenchymal stem cells can detect signalling molecules in the cell environment, offering a new tool to study cell functions in tumours and inflammatory environments.

    • Weian Zhao
    • Sebastian Schafer
    • Jeffrey M. Karp
    Research
    Nature Nanotechnology
    Volume: 6, P: 524-531

  • Lamin and emerin mutations causing cardiomyopathies are associated with an impairment in actin dynamics, resulting in aberrant nuclear translocation and downstream signalling of the transcription factor MKL1, which is pivotal for cardiac development.

    • Chin Yee Ho
    • Diana E. Jaalouk
    • Jan Lammerding
    Research
    Nature
    Volume: 497, P: 507-511

  • Nuclei are subject to various deformations, being pulled, pushed, squeezed and stretched by a plethora of intracellular and extracellular forces. Recent work is unravelling how nuclei sense and respond to these deformations, including with changes in genome organization and function, cell signalling, and cell mechanics.

    • Yohalie Kalukula
    • Andrew D. Stephens
    • Sylvain Gabriele
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 583-602

  • Cryo-electron tomography has provided a means of characterizing the architecture of macromolecular complexes in their native environment, and facilitated a better understanding of cellular processes. By combining this method with fluorescence and super-resolution microscopy, the full potential of this approach can be realized.

    • Karen Fridman
    • Asaf Mader
    • Ohad Medalia
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 736-742