Vaults are massive, cytoplasmic, cage-like ribonucleoprotein assemblies. Here, authors describe cryo-EM structures of human vault encapsulating PARP4 & nucleotide ligands, as well as proteomic data showing that depleting PARP4 alters the vault interactome.
- Jane E. Lodwick
- Rong Shen
- Minglei Zhao