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CD8⁺ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

Aging is associated with the formation of focal white matter lesions and atrophy. The authors discovered a role for CD8⁺ T cells in driving white matter-specific interferon responses in microglia and oligodendrocytes, leading to oligodendrocyte loss.

Tuğberk Kaya
Nicola Mattugini
Mikael Simons
ResearchOpen Access24 Oct 2022
Nature Neuroscience

Volume: 25, P: 1446-1457
Microglia activation orchestrates CXCL10-mediated CD8⁺ T cell recruitment to promote aging-related white matter degeneration

White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8⁺ T cell recruitment, myelinated axon damage and functional decline in aging mice.

Janos Groh
Ruoqing Feng
Mikael Simons
ResearchOpen Access22 May 2025
Nature Neuroscience

Volume: 28, P: 1160-1173
Microglia-mediated demyelination protects against CD8⁺ T cell-driven axon degeneration in mice carrying PLP defects

Demyelination is often suggested to cause axonal degeneration. Here, the authors study mice carrying distinct PLP defects and reveal how persistent ensheathment with perturbed myelin poses a risk for CD8 + T cell-driven axon loss and behavioral decline.

Janos Groh
Tassnim Abdelwahab
Rudolf Martini
ResearchOpen Access30 Oct 2023
Nature Communications

Volume: 14, P: 1-21
Brain-to-gut trafficking of alpha-synuclein by CD11c⁺ cells in a mouse model of Parkinson’s disease

Despite being implicated in several neurological diseases, the gut-brain axis remains poorly understood. Here the authors describe a mechanism of communication between the brain and the gut in a Parkinson’s disease mouse model mediated by CD11c⁺ macrophages.

Rhonda L. McFleder
Anastasiia Makhotkina
Chi Wang Ip
ResearchOpen Access20 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline

Aging is accompanied by structural and functional alterations of the central nervous system (CNS). Here, the authors show that cytotoxic CD8⁺ T cells accumulate in the CNS during normal aging, leading to axonal damage and contributing to age-related cognitive and motor decline.

Janos Groh
Konrad Knöpper
Rudolf Martini
Research15 Apr 2021
Nature Aging

Volume: 1, P: 357-367
Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover

Studies of microglia from a genetic CLN3 disease model indicate loss of the CLN3 protein impacts myelin turnover and lipid metabolism. Impairment to the neuroprotective function of microglia in CLN3 disease is implicated.

Seda Yasa
Elisabeth S. Butz
Susan L. Cotman
ResearchOpen Access22 Oct 2024
Communications Biology

Volume: 7, P: 1-16

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CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration

Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects

Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease

Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline

Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover

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CD8⁺ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

Microglia activation orchestrates CXCL10-mediated CD8⁺ T cell recruitment to promote aging-related white matter degeneration

Microglia-mediated demyelination protects against CD8⁺ T cell-driven axon degeneration in mice carrying PLP defects

Brain-to-gut trafficking of alpha-synuclein by CD11c⁺ cells in a mouse model of Parkinson’s disease