Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–2 of 2 results
Advanced filters: Author: Jasmin C. Aschenbrenner Clear advanced filters

  • The Zika viral protease NS2B-NS3 is a crucial target for antiviral drug development due to its role in processing viral polyproteins. Here, the authors utilize crystallographic fragment screening and deep mutational scanning to identify binding sites for resistance-resilient inhibitors.

    • Xiaomin Ni
    • R. Blake Richardson
    • Frank von Delft
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • The TRIM21 protein’s PRY-SPRY domain is crucial in immune response by recognizing and degrading intracellular antibodies, yet small-molecule targeting remains underexplored. Here, the authors use a crystallographic fragment screening to identify 109 fragment binders distributing across five distinct binding sites of TRIM21, improve the activity by a fragment merging approach, and establish a NanoBRET assay to enable functional validation of compounds.

    • Yeojin Kim
    • Aleksandar Lučić
    • Stefan Knapp
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-11