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Showing 1–4 of 4 results
Advanced filters: Author: Jasper L. Tyler Clear advanced filters

  • When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

    • Balazs Aczel
    • Barnabas Szaszi
    • Brian A. Nosek
    Research
    Nature
    Volume: 652, P: 135-142

  • Visible-light-mediated intramolecular [2+2] cycloaddition of aza-1,6-dienes gives bridged, not fused, heterocycles, in violation of the ‘rule-of-five’, which dictates that five-membered rings are preferentially formed. This method allows a variety of bridged bicyclic scaffolds to be accessed, enabling drug-relevant properties to be readily tuned.

    • Ze-Xin Zhang
    • KaiChen Shu
    • Varinder K. Aggarwal
    ResearchOpen Access
    Nature Synthesis
    P: 1-8

  • Ring-expanding carbon-atom insertion reactions are currently limited to the installation of few functional groups. Now researchers show the use of a radical carbyne precursor for the insertion of carbon atoms bearing varied functional groups to access 2-substituted naphthalenes from indene.

    • Fu-Peng Wu
    • Chetan C. Chintawar
    • Frank Glorius
    Research
    Nature Catalysis
    Volume: 7, P: 242-251

  • The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD+ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.

    • Evandro F. Fang
    • Yujun Hou
    • Vilhelm A. Bohr
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18