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Showing 1–5 of 5 results
Advanced filters: Author: Jasper Panten Clear advanced filters

  • The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape genes upon Xist RNA overexpression in neural progenitors.

    • Antonia Hauth
    • Jasper Panten
    • Agnese Loda
    ResearchOpen Access
    Nature Cell Biology
    Volume: 28, P: 166-181

  • Here the authors find a genetic alteration in the popular “Four Core Genotypes” mouse model that is used to distinguish sex-biased phenotypes caused by sex chromosomes and gonads. This alteration increases the expression of some X-linked genes, which might confound the interpretation of the model.

    • Jasper Panten
    • Stefania Del Prete
    • Duncan T. Odom
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8

  • A technique that combines retrograde axon tracing with single-cell transcriptomics is used to characterize neurons innervating pancreatic ductal adenocarcinoma and healthy pancreas, providing insight into the role of neural connections in cancer progression.

    • Vera Thiel
    • Simon Renders
    • Andreas Trumpp
    ResearchOpen Access
    Nature
    Volume: 640, P: 1042-1051

  • Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential and associated dormancy. Here the authors show that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1, and that decline of netrin-1 production during ageing leads to decreased Neo1 mediated HSC self-renewal.

    • Simon Renders
    • Arthur Flohr Svendsen
    • Andreas Trumpp
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Here the authors show that genetic changes between species often alter gene expression in a cell type-specific manner. Most of this variability is driven by locally functioning cis-acting variation, and this contributes to the speed at which cell types accumulate expression changes.

    • Jasper Panten
    • Tobias Heinen
    • Duncan T. Odom
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13