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Scientific Reports (20)
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Showing 1–50 of 52 results

Advanced filters: Author: Javier Blesa Clear advanced filters

Plasma p-tau217 as a biomarker of Alzheimer’s disease pathology in individuals with Down syndrome

The authors show that phosphorylated tau 217 is an accurate blood-based biomarker to detect Alzheimer’s disease and predict disease progression in individuals with Down syndrome, supporting its use as a reliable, non-invasive tool for early diagnosis and care.

Hanna Huber
Javier Arranz
Nicholas J. Ashton
ResearchOpen Access10 Nov 2025
Nature Communications

Volume: 16, P: 1-8
Infographic: SPECTRUM: study design of the global real-world study of aflibercept 8 mg in the treatment of neovascular age-related macular degeneration and diabetic macular edema

Clare Bailey
Clemens Lange
Vasileios Konidaris
ResearchOpen Access16 Jan 2026
Eye

P: 1-4
Electrophysiological findings in long-term type 1 diabetes patients without diabetic retinopathy using different ERG recording systems

Marta Arias-Alvarez
Cristina Tomas-Grasa
Isabel Pinilla
ResearchOpen Access12 Feb 2024
Scientific Reports

Volume: 14, P: 1-13
Treatment intervals with first-generation anti-vascular endothelial growth factor drugs: evaluating the unmet need in a real-world neovascular age-related macular degeneration national database

Javier Zarranz-Ventura
Gonzaga Garay-Aramburu
Ana Campo Gesto
ResearchOpen Access16 Oct 2025
Eye

Volume: 39, P: 3306-3313
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

Julius Gudmundsson
Patrick Sulem
Kari Stefansson
Research10 Feb 2008
Nature Genetics

Volume: 40, P: 281-283
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?

A prevailing theory of Parkinson disease pathogenesis revolves around the spread of α-synuclein toxicity from the periphery to the brain. In this Review, Blesa and colleagues discuss the idea that, although these bottom-up mechanisms are involved, early neuronal loss in the nigrostriatal system also plays a prominent role.

Javier Blesa
Guglielmo Foffani
Jose A. Obeso
Reviews14 Dec 2021
Nature Reviews Neuroscience

Volume: 23, P: 115-128
Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration

The microbiota of the intestinal tract is considered a large biofilm formed by myriads bacteria that have a considerable impact in health and disease. Here, the authors show that biofilm-associated proteins from intestinal microbiota form amyloid-like structures that exacerbate alpha-synuclein pathologies.

Ariadna Fernández-Calvet
Leticia Matilla-Cuenca
Jaione Valle
ResearchOpen Access16 May 2024
Nature Communications

Volume: 15, P: 1-19
The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

The bacterium Helicobacter pylori, often found in the human stomach, can be classified into distinct subpopulations associated with the geographic origin of the host. Here, the authors provide insights into H. pylori population structure by collecting over 1,000 clinical strains from 50 countries and generating and analyzing high-quality bacterial genome sequences.

Kaisa Thorell
Zilia Y. Muñoz-Ramírez
Charles S. Rabkin
ResearchOpen Access11 Dec 2023
Nature Communications

Volume: 14, P: 1-16
Brolucizumab clinical and safety outcomes in a neovascular age-related macular degeneration national database: Fight Retinal Blindness Spain (FRB Spain)

Javier Zarranz-Ventura
Sonia Marías-Pérez
Lucia Miguel-Escuder
Research05 Jun 2025
Eye

Volume: 39, P: 2407-2414
Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs

Samuel J. Martínez-Domínguez
Sandra García-Mateo
Pedro M. Baptista
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-11
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

In a post-approval study including more than 17,000 patients on the safety of pulsed field ablation, a new method for treatment of atrial fibrillation, the procedure was found to have a low rate of adverse events but was associated with some unexpected rare complications that will need further study.

Emmanuel Ekanem
Petr Neuzil
Vivek Y. Reddy
ResearchOpen Access08 Jul 2024
Nature Medicine

Volume: 30, P: 2020-2029
Endomapper dataset of complete calibrated endoscopy procedures

Pablo Azagra
Carlos Sostres
José M. M. Montiel
ResearchOpen Access03 Oct 2023
Scientific Data

Volume: 10, P: 1-16
Comparison of several Real-Time PCR Kits versus a Culture-dependent Algorithm to Identify Enteropathogens in Stool Samples

Silvia Valledor
Inés Valledor
Javier Castillo
ResearchOpen Access09 Mar 2020
Scientific Reports

Volume: 10, P: 1-8
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

Mariana G. López
Álvaro Chiner-Oms
Iñaki Comas
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1405-1414
A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families

Genetic factors that cause cardiac angiosarcoma are unknown. Calveteet al. show that a missense mutation in protection of telomeres1 (POT1) gene causes cardiac angiosarcoma by affecting the POT1 function and, consequently, telomere length and stability.

Oriol Calvete
Paula Martinez
Javier Benítez
ResearchOpen Access25 Sept 2015
Nature Communications

Volume: 6, P: 1-12
Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children’s Cohort and Implications of the Gene in Adipocyte Metabolism

Francisco Javier Ruiz-Ojeda
Augusto Anguita-Ruiz
Concepcion Maria Aguilera
ResearchOpen Access08 Mar 2019
Scientific Reports

Volume: 9, P: 1-16
Spread of a SARS-CoV-2 variant through Europe in the summer of 2020

Analysis of the spread of the 20E (EU1) variant of SARS-CoV-2 through Europe suggests that international travel and insufficient containment, rather than increased transmissibility, led to a resurgence of infections.

Emma B. Hodcroft
Moira Zuber
Richard A. Neher
Research07 Jun 2021
Nature

Volume: 595, P: 707-712
Intravenous iron in IBD—what's the best preparation?

Iron deficiency anemia can occur secondary to IBD. A new clinical trial demonstrates that ferric carboxymaltose is more cost-effective, convenient and efficacious than iron sucrose for treating iron deficiency anemia in patients with IBD, an innovation that could make anemia treatment easier for clinicians, patients and health-care providers alike.

Fernando Gomollón
Javier P. Gisbert
News & Views26 Jul 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 477-478
Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

Luis Jara-Palomares
Maria Alfonso
Abilio Reis
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
Resilience of striatal synaptic plasticity over early structural adaptations in premotor parkinsonism

Leyre Merino-Galán
Marta Zamarbide
María Cruz Rodríguez-Oroz
ResearchOpen Access03 Jun 2025
npj Parkinson's Disease

Volume: 11, P: 1-13
ECG-based evaluation of ventricular synchrony in left bundle branch area pacing through characterization of the activation sequence

Clara Sales-Belles
Ana Mincholé
Javier Ramos-Maqueda
ResearchOpen Access04 May 2025
Scientific Reports

Volume: 15, P: 1-12
Food groups associated with immune-mediated inflammatory diseases: a Mendelian randomization and disease severity study

Antonio Julià
Sergio H. Martínez-Mateu
Adrià Aterido
Research23 Apr 2021
European Journal of Clinical Nutrition

Volume: 75, P: 1368-1382
Identification of neurodegenerative factors using translatome–regulatory network analysis

To elucidate novel molecular mechanisms underlying neurodegeneration in Parkinson's disease, the authors generated mice for cell type-specific profiling of dopaminergic neurons. Regulatory network analysis of translatome libraries from dopaminergic neurons under degenerative stress facilitated the identification of intrinsic upstream regulators that oppose degeneration. This strategy can be generalized to investigate degeneration of other classes of neurons.

Lars Brichta
William Shin
Paul Greengard
Research27 Jul 2015
Nature Neuroscience

Volume: 18, P: 1325-1333
Flow cytometry for fast screening and automated risk assessment in systemic light-chain amyloidosis

Noemi Puig
Bruno Paiva
Jesús F. San Miguel
Research12 Dec 2018
Leukemia

Volume: 33, P: 1256-1267
HER2 and hormone receptor-positive breast cancer—blocking the right target

Chemotherapy and trastuzumab is standard therapy for HER2-positive breast cancer, although aromatase inhibitors combined with anti-HER2 therapies is an option in patients with HER2 and hormone receptor-positive tumors. The activity observed with chemotherapy and anti-HER2 therapies seems to be higher than with aromatase inhibitors and HER-2-based therapies. The authors highlight the data that have led to current treatment strategies and the importance of considering chemotherapy and anti-HER2 therapy for HER2 and hormone receptor-positive tumors.

Javier Cortés
Cristina Saura
María Vidal
Reviews14 Dec 2010
Nature Reviews Clinical Oncology

Volume: 8, P: 307-311
Unsupervised machine learning improves risk stratification in newly diagnosed multiple myeloma: an analysis of the Spanish Myeloma Group

Adrian Mosquera Orgueira
Marta Sonia González Pérez
Maria Victoria Mateos
ResearchOpen Access25 Apr 2022
Blood Cancer Journal

Volume: 12, P: 1-9
Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma

Javier Fernández-Mateos
Raquel Seijas-Tamayo
Rogelio González-Sarmiento
ResearchOpen Access31 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy

F. David Carmona
Patrick Coit
Steven R. Ytterberg
ResearchOpen Access09 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model

Natalia López-González del Rey
Nagore Hernández-Pinedo
Javier Blesa
ResearchOpen Access02 Sept 2024
npj Parkinson's Disease

Volume: 10, P: 1-15
Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates

Tiziano Balzano
Natalia López-González del Rey
Javier Blesa
ResearchOpen Access17 Jun 2024
npj Parkinson's Disease

Volume: 10, P: 1-11
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24

Julius Gudmundsson
Patrick Sulem
Kari Stefansson
Research01 Apr 2007
Nature Genetics

Volume: 39, P: 631-637
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility

Julius Gudmundsson and colleagues report a prostate cancer genome-wide association follow-on study. They report variants at 3q21.3, 8q24.21 and 19q13.2 newly associated to prostate cancer susceptibility and the fine-mapping of the association signal at 11q13.

Julius Gudmundsson
Patrick Sulem
Kari Stefansson
Research20 Sept 2009
Nature Genetics

Volume: 41, P: 1122-1126
X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline

Augusto Anguita-Ruiz
Julio Plaza-Diaz
Concepción María Aguilera
ResearchOpen Access22 Jul 2019
Scientific Data

Volume: 6, P: 1-10
Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality

Joaquín Martínez-López
María-Victoria Mateos
Jesús San-Miguel
ResearchOpen Access19 Oct 2020
Blood Cancer Journal

Volume: 10, P: 1-11
Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody

Guillermo Valenzuela Nieto
Ronald Jara
Alejandro Rojas-Fernandez
ResearchOpen Access08 Feb 2021
Scientific Reports

Volume: 11, P: 1-14
Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

Luis Felipe Reyes
Alejandro Rodriguez
Neus Guasch
ResearchOpen Access21 Apr 2023
Scientific Reports

Volume: 13, P: 1-15
Predictive study of pharmacological reversal for residual neuromuscular blockade and postoperative pulmonary complications: a prospective, observational, cohort study

Cristian Aragón-Benedí
Ana Pascual-Bellosta
Francisco Romero-Caro
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients

José Luis Piñana
Lourdes Vazquez
Rodrigo Martino
ResearchOpen Access05 Jan 2023
Blood Cancer Journal

Volume: 13, P: 1-14
A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma

Cristina Encinas
José-Ángel Hernandez-Rivas
Joaquín Martínez-López
ResearchOpen Access19 Apr 2022
Blood Cancer Journal

Volume: 12, P: 1-8
Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension

Alfredo Guillén-Del-Castillo
Manuel López Meseguer
José Antonio Vargas Hitos
ResearchOpen Access28 Mar 2022
Scientific Reports

Volume: 12, P: 1-11
Changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs

Elvira Orduna-Hospital
Ana Sanchez-Cano
Isabel Pinilla
ResearchOpen Access17 May 2021
Scientific Reports

Volume: 11, P: 1-10
Immunogenetic characterization of clonal plasma cells in systemic light-chain amyloidosis

Isabel Cuenca
Daniel Alameda
Joaquin Martinez-Lopez
ResearchOpen Access19 Mar 2020
Leukemia

Volume: 35, P: 245-249
Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance

Tania Calvo
Chantal Reina-Ortiz
Alberto Anel
ResearchOpen Access10 Nov 2020
Scientific Reports

Volume: 10, P: 1-14
Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA

Andrés González
Sandra Salillas
Ángel Lanas
ResearchOpen Access05 Aug 2019
Scientific Reports

Volume: 9, P: 1-13
X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients

Clara Xiol
Silvia Vidal
Cristina Villar
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-9
Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)

Carolina Beltrán-Pavez
Miguel Gutiérrez-López
Elisa Lazzari
ResearchOpen Access09 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
The utility of Next Generation Sequencing for molecular diagnostics in Rett syndrome

Silvia Vidal
Núria Brandi
Cristina Villar
ResearchOpen Access25 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
Author Correction: Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension

Alfredo Guillén-Del-Castillo
Manuel López Meseguer
José Antonio Vargas Hitos
Amendments and CorrectionsOpen Access28 Jul 2022
Scientific Reports

Volume: 12, P: 1
Secondary malignancies and survival outcomes after autologous stem cell transplantation for follicular lymphoma in the pre-rituximab and rituximab eras: a long-term follow-up analysis from the Spanish GELTAMO registry

Ana Jiménez-Ubieto
Carlos Grande
Juan José Lahuerta
Correspondence23 Jan 2018
Bone Marrow Transplantation

Volume: 53, P: 780-783

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