Nature Search

A brain-wide map of neural activity during complex behaviour

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

Leenoy Meshulam
Dora Angelaki
Ilana B. Witten
ResearchOpen Access03 Sept 2025
Nature

Volume: 645, P: 177-191
Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity

Genomic, transcriptomic and epigenetic analyses of malignant pleural mesothelioma identify molecular axes and specialized tumor profiles underlying intertumoral heterogeneity.

Lise Mangiante
Nicolas Alcala
Lynnette Fernandez-Cuesta
ResearchOpen Access16 Mar 2023
Nature Genetics

Volume: 55, P: 607-618
Brain-wide representations of prior information in mouse decision-making

Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.

Charles Findling
Félix Hubert
Alexandre Pouget
ResearchOpen Access03 Sept 2025
Nature

Volume: 645, P: 192-200
NIPMAP: niche-phenotype mapping of multiplex histology data by community ecology

Multiplex histology faces the challenge of integrating tissue architecture with the identification of relevant spatial cellular phenotypes. Using community ecology principles, the authors propose NIPMAP, a tool for niche-phenotype mapping of multiplex histology data.

Anissa El Marrahi
Fabio Lipreri
Jean Hausser
ResearchOpen Access07 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Microenvironmental reorganization in brain tumors following radiotherapy and recurrence revealed by hyperplexed immunofluorescence imaging

Improved imaging techniques are required to help advance our understanding of the complex role of the tumour microenvironment (TME). Here, the authors develop a high-throughput, highly multiplexed tissue visualisation workflow and demonstrate its utility by characterising the response of the TME to radiotherapy in preclinical models of glioblastoma.

Spencer S. Watson
Benoit Duc
Johanna A. Joyce
ResearchOpen Access15 Apr 2024
Nature Communications

Volume: 15, P: 1-16
Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

Romani et al. identify a response to reduced actomyosin contractility involving inhibition of Lipin-1, accumulation of SREBP transcription factors at the Golgi apparatus and activation of SREBP transcription driving increased lipid synthesis.

Patrizia Romani
Irene Brian
Sirio Dupont
Research04 Feb 2019
Nature Cell Biology

Volume: 21, P: 338-347
Interneuron- and GABA_A receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells

Rebound potentiation (RP), a form of inhibitory plasticity in the cerebellum, is characterized by an increase in GABAergic synaptic currents. Here the authors demonstrate that RP is both interneuron input-specific and GABA_Areceptor subunit-specific and serves to regulate Purkinje cell firing patterns.

Qionger He
Ian Duguid
Trevor G. Smart
ResearchOpen Access16 Jul 2015
Nature Communications

Volume: 6, P: 1-13
Erratum: Identification and consequences of miRNA–target interactions — beyond repression of gene expression

Jean Hausser
Mihaela Zavolan
Amendments and Corrections16 Sept 2014
Nature Reviews Genetics

Volume: 15, P: 702
Central dogma rates and the trade-off between precision and economy in gene expression

The same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise.

Jean Hausser
Avi Mayo
Uri Alon
ResearchOpen Access08 Jan 2019
Nature Communications

Volume: 10, P: 1-15
A common computational and neural anomaly across mouse models of autism

Noel et al. show aberrant updating of expectations in three distinct mouse models of autism spectrum disorder. Brain-wide neurophysiology data suggest this stems from excess units encoding deviations from prior mean and a lack of sensory prediction errors in frontal areas.

Jean-Paul Noel
Edoardo Balzani
Dora E. Angelaki
Research03 Jun 2025
Nature Neuroscience

Volume: 28, P: 1519-1532
Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling and cloud-native open-source tools

Lightning Pose is an efficient pose estimation approach that requires few labeled training data owing to its semi-supervised learning strategy and ensembling.

Dan Biderman
Matthew R. Whiteway
Liam Paninski
Research25 Jun 2024
Nature Methods

Volume: 21, P: 1316-1328
Tumor diversity and the trade-off between universal cancer tasks

The evolutionary trade-offs faced by tumors are poorly understood, yet could contribute to the molecular diversity of cancer. Here, the authors analyze the diversity of genetic alterations, genes expressed and drug sensitivities among solid tumors to explore what evolutionary trade-offs may explain the molecular diversity of tumors.

Jean Hausser
Pablo Szekely
Uri Alon
ResearchOpen Access28 Nov 2019
Nature Communications

Volume: 10, P: 1-13
Inferring biological tasks using Pareto analysis of high-dimensional data

Pareto task inference (ParTI) computes a polytype that encloses a data set and determines the enrichment of features around the vertices (archetypes) of the polytype, which allows the identification of the task the archetype represents.

Yuval Hart
Hila Sheftel
Uri Alon
Research26 Jan 2015
Nature Methods

Volume: 12, P: 233-235
Diffusion Smart-seq3 of breast cancer spheroids to explore spatial tumor biology and test evolutionary principles of tumor heterogeneity

Antony Cougnoux
Loay Mahmoud
Jean Hausser
ResearchOpen Access30 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials

At chemical synapses, the dynamic membrane potential of a neuron must be converted into a train of spikes. Here, the authors conceptualize the neuron's efferent synapses as estimating the membrane potential trajectory from the spikes. They find that short-term changes in synaptic efficacy can be interpreted as implementing an optimal estimator.

Jean-Pascal Pfister
Peter Dayan
Máté Lengyel
Research19 Sept 2010
Nature Neuroscience

Volume: 13, P: 1271-1275
PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans

Catherine André, Judith Fischer and colleagues report that mutations in PNPLA1 cause congenital ichthyosis in humans and golden retriever dogs. Their findings suggest a role for PNPLA1 in the formation of the epidermal lipid barrier.

Anaïs Grall
Eric Guaguère
Judith Fischer
Research15 Jan 2012
Nature Genetics

Volume: 44, P: 140-147
Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

Jing-wen Lin
Jan Sodenkamp
Jean Langhorne
ResearchOpen Access03 Feb 2017
Scientific Reports

Volume: 7, P: 1-13
Tumour heterogeneity and the evolutionary trade-offs of cancer

This Perspective discusses the theory of multi-task evolution in cancer, which can contribute to understanding tumour diversity. It introduces the concept of generalist and specialist tumours in the contexts of driver mutations and discusses the potential applications to interpret intratumour heterogeneity.

Jean Hausser
Uri Alon
Reviews24 Feb 2020
Nature Reviews Cancer

Volume: 20, P: 247-257
A modular architecture for organizing, processing and sharing neurophysiology data

A modular architecture for managing and sharing electrophysiology, behavior, colony management and other data has been built to support individual laboratories or large consortia.

Luigi Acerbi
Valeria Aguillon-Rodriguez
Miles J. Wells
Research02 Mar 2023
Nature Methods

Volume: 20, P: 403-407
Isolation of skin-derived precursors (SKPs) and differentiation and enrichment of their Schwann cell progeny

Jeffrey A Biernaskie
Ian A McKenzie
Freda D Miller
Protocols25 Jan 2007
Nature Protocols

Volume: 1, P: 2803-2812
Spike timing of dendrite-targeting bistratified cells during hippocampal network oscillations in vivo

Thomas Klausberger
László F Márton
Peter Somogyi
Research23 Nov 2003
Nature Neuroscience

Volume: 7, P: 41-47
Identification and consequences of miRNA–target interactions — beyond repression of gene expression

This Review discusses the main experimental approaches for microRNA (miRNA) target identification, as well as the modulators and the consequences of miRNA–target interactions. It also highlights the role of computational modelling in furthering the conceptual understanding of miRNA functions in gene regulatory networks.

Jean Hausser
Mihaela Zavolan
Reviews15 Jul 2014
Nature Reviews Genetics

Volume: 15, P: 599-612
A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets

This microRNA target–prediction program, based on biophysical parameters of mRNA and microRNA, outperforms current programs when it comes to finding noncanonical sites.

Mohsen Khorshid
Jean Hausser
Erik van Nimwegen
Research20 Jan 2013
Nature Methods

Volume: 10, P: 253-255
A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins

The comparison of cross-linking and immunoprecipitation (CLIP) and photoactivatable ribonucleoside–enhanced CLIP (PAR-CLIP) protocols shows specific biases of each method in enriching subsets of binding sites of RNA-binding proteins and shows ways around these biases.

Shivendra Kishore
Lukasz Jaskiewicz
Mihaela Zavolan
Research15 May 2011
Nature Methods

Volume: 8, P: 559-564
MicroRNAs 103 and 107 regulate insulin sensitivity

Mirko Trajkovski
Jean Hausser
Markus Stoffel
Research08 Jun 2011
Nature

Volume: 474, P: 649-653

Search

A brain-wide map of neural activity during complex behaviour

Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity

Brain-wide representations of prior information in mouse decision-making

NIPMAP: niche-phenotype mapping of multiplex histology data by community ecology

Microenvironmental reorganization in brain tumors following radiotherapy and recurrence revealed by hyperplexed immunofluorescence imaging

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

Interneuron- and GABA_A receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells

Erratum: Identification and consequences of miRNA–target interactions — beyond repression of gene expression

Central dogma rates and the trade-off between precision and economy in gene expression

A common computational and neural anomaly across mouse models of autism

Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling and cloud-native open-source tools

Tumor diversity and the trade-off between universal cancer tasks

Inferring biological tasks using Pareto analysis of high-dimensional data

Diffusion Smart-seq3 of breast cancer spheroids to explore spatial tumor biology and test evolutionary principles of tumor heterogeneity

Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials

PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans

Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

Tumour heterogeneity and the evolutionary trade-offs of cancer

A modular architecture for organizing, processing and sharing neurophysiology data

Isolation of skin-derived precursors (SKPs) and differentiation and enrichment of their Schwann cell progeny

Spike timing of dendrite-targeting bistratified cells during hippocampal network oscillations in vivo

Identification and consequences of miRNA–target interactions — beyond repression of gene expression

A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets

A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins

MicroRNAs 103 and 107 regulate insulin sensitivity

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