Nature Search

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Telomerase reverse-trancriptase promoter mutations have been recently found in human melanomas. Here, Nault et al.identify telomerase reverse-trancriptase promoter mutations as the most frequent somatic genetic alterations in hepatocellular carcinomas and as the first mutation identified in cirrhotic preneoplastic lesions.

Jean Charles Nault
Maxime Mallet
Jessica Zucman-Rossi
ResearchOpen Access26 Jul 2013
Nature Communications

Volume: 4, P: 1-7
Survival in patients receiving reduced dose intensity of bevacizumab for unresectable hepatocellular carcinoma

Dimity Ball
Jean-Charles Nault
Rohini Sharma
ResearchOpen Access06 May 2025
npj Precision Oncology

Volume: 9, P: 1-5
Cholangiocarcinoma 2026: status quo, unmet needs and priorities

In this Consensus Statement, an international panel of experts present an overview of the latest developments in the field of cholangiocarcinoma. A set of consensus recommendations and research priorities is provided.

Jesus M. Banales
Pedro M. Rodrigues
Victor Lopez-Lopez
Reviews10 Dec 2025
Nature Reviews Gastroenterology & Hepatology

Volume: 23, P: 65-96
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Jessica Zucman-Rossi and colleagues report exome sequences of 243 hepatocellular carcinomas. They identify mutational signatures associated with specific risk factors such as alcohol, tobacco and aflatoxin B1 and find genetic alterations potentially targetable by FDA-approved drugs in 28% of the tumors.

Kornelius Schulze
Sandrine Imbeaud
Jessica Zucman-Rossi
Research30 Mar 2015
Nature Genetics

Volume: 47, P: 505-511
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

Jessica Zucman-Rossi and colleagues identify clonal integrations of adeno-associated virus type 2 (AAV2) in hepatocellular carcinomas. These AAV2 integrations occurred within known cancer driver genes, suggesting a pathogenic role of AAV2 in these patients.

Jean-Charles Nault
Shalini Datta
Jessica Zucman-Rossi
Research24 Aug 2015
Nature Genetics

Volume: 47, P: 1187-1193
Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress

Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to display replication stress-induced structural rearrangements frequently activating TERT promoter.

Quentin Bayard
Léa Meunier
Eric Letouzé
ResearchOpen Access07 Dec 2018
Nature Communications

Volume: 9, P: 1-14
A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

In Trp53-mutated hepatocellular carcinoma, conformation-changing aurora kinase A inhibitors disrupt aurora kinase A–MYC interactions, resulting in MYC degradation and suppression of tumor growth.

Daniel Dauch
Ramona Rudalska
Lars Zender
Research23 May 2016
Nature Medicine

Volume: 22, P: 744-753
Benign liver tumours: understanding molecular physiology to adapt clinical management

Here, the authors provide an overview of benign liver tumours (hepatic haemangioma, focal nodular hyperplasia and hepatocellular adenoma), including pathogenesis, diagnosis and management. Insights into how molecular physiology could inform clinical practice are also highlighted.

Jean-Charles Nault
Valérie Paradis
Jessica Zucman-Rossi
Reviews14 Jul 2022
Nature Reviews Gastroenterology & Hepatology

Volume: 19, P: 703-716
The role of telomeres and telomerase in cirrhosis and liver cancer

Telomerase is a key enzyme for cell survival that prevents telomere shortening. In this Review, the roles of telomeres and telomerase in cirrhosis and liver carcinogenesis are discussed, in addition to their potential in clinical practice as biomarkers and therapeutic targets.

Jean-Charles Nault
Massih Ningarhari
Jessica Zucman-Rossi
Reviews28 Jun 2019
Nature Reviews Gastroenterology & Hepatology

Volume: 16, P: 544-558
Imaging and histological features of tumor biopsy sample predict aggressive intrasegmental recurrence of hepatocellular carcinoma after radiofrequency ablation

Elia Gigante
Yohann Haddad
Marianne Ziol
ResearchOpen Access04 Nov 2022
Scientific Reports

Volume: 12, P: 1-12

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