Nature Search

Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trial

An implantable vagus nerve-targeted device safely reduces disease activity and joint damage in rheumatoid arthritis, offering a new nondrug treatment for patients who do not respond to or cannot tolerate medication.

John R. P. Tesser
Angela R. Crowley
David Chernoff
ResearchOpen Access22 Dec 2025
Nature Medicine

Volume: 32, P: 369-378
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Author Correction: Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging

John S. H. Danial
Jeff Y. L. Lam
David Klenerman
Amendments and Corrections27 Sept 2023
Nature Protocols

Volume: 18, P: 3975
Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer

As cervical tumours become more invasive, levels of episomal human papillomavirus paradoxically tend to decrease. Here the authors identify a network of antiviral and cell cycle genes that is amplified by chromosomal aberrations and promotes cervical tumour progression.

Karina L. Mine
Natalia Shulzhenko
Andrey Morgun
Research07 May 2013
Nature Communications

Volume: 4, P: 1-11
Flipping APOE to reverse Alzheimer’s disease traits

In this issue of Nature Neuroscience, Golden et al. unveil a mouse model that enables in vivo ‘switching’ from the Alzheimer’s risk gene APOE4 to the protective gene APOE2. This genetic conversion reshapes Alzheimer’s disease-related metabolism, reduces neuropathology, and enhances cognition, demonstrating the beneficial effects of APOE genetic targeting as a promising therapeutic strategy.

Jeff Y. L. Lam
Kai Wang
Guojun Bu
News & Views11 Nov 2025
Nature Neuroscience

Volume: 28, P: 2407-2409
A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides

Parkinson’s disease (PD) is linked to environmental factors. Through quantitative epidemiology, this study ties 53 pesticides to PD. An innovative human stem cell platform revealed that 10 of these were directly toxic to human dopamine neurons.

Kimberly C. Paul
Richard C. Krolewski
Beate Ritz
ResearchOpen Access16 May 2023
Nature Communications

Volume: 14, P: 1-18
Joint speech and text machine translation for up to 100 languages

SEAMLESSM4T is a single machine translation tool that supports speech-to-speech translation, speech-to-text translation, text-to-speech translation, text-to-text translation and automatic speech recognition between up to 100 languages.

Loïc Barrault
Yu-An Chung
Skyler Wang
ResearchOpen Access15 Jan 2025
Nature

Volume: 637, P: 587-593
Scaling neural machine translation to 200 languages

Scaling neural machine translation to 200 languages is achieved by No Language Left Behind, a single massively multilingual model that leverages transfer learning across languages.

Marta R. Costa-jussà
James Cross
Jeff Wang
ResearchOpen Access05 Jun 2024
Nature

Volume: 630, P: 841-846
A map of human genome variation from population-scale sequencing

The goal of the 1000 Genomes Project is to provide in-depth information on variation in human genome sequences. In the pilot phase reported here, different strategies for genome-wide sequencing, using high-throughput sequencing platforms, were developed and compared. The resulting data set includes more than 95% of the currently accessible variants found in any individual, and can be used to inform association and functional studies.

Richard M. Durbin
David Altshuler (Co-Chair)
Gil A. McVean
ResearchOpen Access27 Oct 2010
Nature

Volume: 467, P: 1061-1073
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma

TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models.

Jeff Yat-Fai Chung
Philip Chiu-Tsun Tang
Patrick Ming-Kuen Tang
ResearchOpen Access31 Mar 2023
Nature Communications

Volume: 14, P: 1-17
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Here the authors connect inherited Apolipoprotein E genotype with the risk of developing Alzheimer’s disease by demonstrating how, in an isoform- and lipidation-specific way, apoE modulates the aggregation, clearance and toxicity of Amyloid-beta.

Zengjie Xia
Emily E. Prescott
Suman De
ResearchOpen Access01 Jun 2024
Nature Communications

Volume: 15, P: 1-18
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease

α-synuclein aggregates cause neuronal damage, but their heterogeneity complicates studying their toxic properties. Here, the authors analyze α-synuclein aggregates in vitro and study post-mortem brain samples, providing evidence that small aggregates are the main culprit for neuronal death in Parkinson’s disease.

Derya Emin
Yu P. Zhang
David Klenerman
ResearchOpen Access20 Sept 2022
Nature Communications

Volume: 13, P: 1-15
Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging

This protocol provides a step-by-step guide to building an affordable single-molecule localization microscopy setup for high-throughput super-resolution imaging by using off-the-shelf and machined parts.

John S. H. Danial
Jeff Y. L. Lam
David Klenerman
Protocols24 Aug 2022
Nature Protocols

Volume: 17, P: 2570-2619
An integrated encyclopedia of DNA elements in the human genome

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Ian Dunham
Anshul Kundaje
Ewan Birney
ResearchOpen Access05 Sept 2012
Nature

Volume: 489, P: 57-74
Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Tumor–normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking ‘tumor-only’ or ‘matched tumor–normal’ analyses.

Li Tai Fang
Bin Zhu
Yuanting Zheng
Research09 Sept 2021
Nature Biotechnology

Volume: 39, P: 1151-1160
Detection of p53 aggregates in plasma of glioma patients

Wu et al. develop an ultrasensitive immunoassay based on the single-molecule array (SiMoA) technology to detect p53 aggregates in plasma. They show that the p53 aggregate concentrations in the plasma of pre-surgery glioblastoma patients are significantly higher compared to controls.

Yunzhao Wu
Jeff Y. L. Lam
David Klenerman
ResearchOpen Access23 May 2025
Communications Medicine

Volume: 5, P: 1-11
Reproducible pharmacogenomic profiling of cancer cell line panels

Large-scale analyses of the drug sensitivity of cancer cell lines have been previously reported to yield conflicting conclusions; this Analysis uses independently generated data to demonstrate that consistency can be achieved if key laboratory and data analysis practices are considered when future studies are undertaken.

Peter M. Haverty
Eva Lin
Richard Bourgon
Research18 May 2016
Nature

Volume: 533, P: 333-337
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Magnesium homeostasis protects Salmonella against nitrooxidative stress

Travis J. Bourret
Lin Liu
Andrés Vázquez-Torres
ResearchOpen Access08 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy

Emre Fertan
Dorothea Böken
David Klenerman
ResearchOpen Access15 Dec 2023
Molecular Psychiatry

Volume: 29, P: 369-386
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Increased Seasonal Variation in Serotonin Transporter Binding in Seasonal Affective Disorder

Andrea E Tyrer
Robert D Levitan
Jeffrey H Meyer
Research18 Apr 2016
Neuropsychopharmacology

Volume: 41, P: 2447-2454
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trial

Mapping the human genetic architecture of COVID-19

Author Correction: Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging

Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer

Flipping APOE to reverse Alzheimer’s disease traits

A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides

Joint speech and text machine translation for up to 100 languages

Scaling neural machine translation to 200 languages

A map of human genome variation from population-scale sequencing

Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Whole-genome sequencing reveals host factors underlying critical COVID-19

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease

Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging

An integrated encyclopedia of DNA elements in the human genome

Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Detection of p53 aggregates in plasma of glioma patients

Reproducible pharmacogenomic profiling of cancer cell line panels

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Magnesium homeostasis protects Salmonella against nitrooxidative stress

Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Increased Seasonal Variation in Serotonin Transporter Binding in Seasonal Affective Disorder

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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