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Showing 1–12 of 12 results
Advanced filters: Author: Jennifer A. Prescher Clear advanced filters

  • Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultrasensitive platform for RNA imaging, which features RNA tags that recruit light-emitting luciferase fragments.

    • Lila P. Halbers
    • Kyle H. Cole
    • Jennifer A. Prescher
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • The synthetic firefly luciferase substrate CycLuc1 offers brighter bioluminescence and improved imaging in mouse models at lower doses than the standard D-luciferin.

    • Melanie S Evans
    • Joanna P Chaurette
    • Stephen C Miller
    Research
    Nature Methods
    Volume: 11, P: 393-395

  • The combination of engineered probes and spectral phasor analysis overcomes long-standing challenges associated with bioluminescence detection at the microscale, enabling multiplexed, real-time imaging of cellular features without the need for excitation light.

    • Zi Yao
    • Caroline K. Brennan
    • Jennifer A. Prescher
    Research
    Nature Methods
    Volume: 19, P: 893-898

  • Cell-to-cell signaling networks, although poorly understood, guide tissue development, regulate tissue function and may become dysregulated in disease. Chemical biologists can develop the next generation of tools to untangle these complex and dynamic networks of interacting cells.

    • Zev J Gartner
    • Jennifer A Prescher
    • Luke D Lavis
    Comments & Opinion
    Nature Chemical Biology
    Volume: 13, P: 564-568

  • Tagging and manipulating biomolecules in living systems requires precisely tuned, biocompatible reactions. This Review focuses on recent advances in the development of bioorthogonal reactions, with an emphasis on how mechanistic insights have driven the field.

    • Sean S. Nguyen
    • Jennifer A. Prescher
    Reviews
    Nature Reviews Chemistry
    Volume: 4, P: 476-489

  • The underlying mechanisms and optimal conditions that drive biorthogonal reactions and the utility of these for applications in medicinal chemistry and protein synthesis to polymers and materials science are described in this Primer. Current reproducibility standards and how current reaction limitations are driving new research efforts are also discussed.

    • Samuel L. Scinto
    • Didier A. Bilodeau
    • Joseph M. Fox
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-23