Nature Search

Crystal structure of the DsbA protein required for disulphide bond formation in vivo

Jennifer L. Martin
James C. A. Bardwell
John Kuriyan
Research30 Sept 1993
Nature

Volume: 365, P: 464-468
Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention

Integrated analyses reveal that multiomics captured the heterogeneity of metabolic states accompanying obesity and changes in metabolic health in response to lifestyle intervention that are not apparent in body mass index measurements.

Kengo Watanabe
Tomasz Wilmanski
Noa Rappaport
ResearchOpen Access20 Mar 2023
Nature Medicine

Volume: 29, P: 996-1008
Stress responses in an Arctic microalga (Pelagophyceae) following sudden salinity change revealed by gene expression analysis

The authors analyzed the response of an Arctic pelagophyte to lowered salinity. They observed that several ancient and widespread pathways were activated, allowing the species to adjust to the stress of rapid salinity change.

Nastasia J. Freyria
Thais C. de Oliveira
Connie Lovejoy
ResearchOpen Access04 Sept 2024
Communications Biology

Volume: 7, P: 1-14
Author Correction: Gut microbiome pattern reflects healthy ageing and predicts survival in humans

Tomasz Wilmanski
Christian Diener
Nathan D. Price
Amendments and Corrections18 Mar 2021
Nature Metabolism

Volume: 3, P: 586
A wellness study of 108 individuals using personal, dense, dynamic data clouds

Longitudinal clinical and multi-omics data from 108 healthy individuals are analyzed to identify putative biomarkers and diagnostics of early disease states.

Nathan D Price
Andrew T Magis
Leroy Hood
Research17 Jul 2017
Nature Biotechnology

Volume: 35, P: 747-756
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Type I PRMT inhibition elicits potent antitumor activity associated with increased interferon response and intron-retained dsRNA accumulation, suggesting its potential combination with immune checkpoint inhibitors for cancer treatment.

Qin Wu
David Y. Nie
Cheryl H. Arrowsmith
ResearchOpen Access16 May 2022
Nature Chemical Biology

Volume: 18, P: 821-830
Blood metabolome predicts gut microbiome α-diversity in humans

Multiomics reveals that almost half of gut microbiome diversity in humans can be explained by 40 blood metabolites.

Tomasz Wilmanski
Noa Rappaport
Nathan D. Price
Research02 Sept 2019
Nature Biotechnology

Volume: 37, P: 1217-1228
Gut microbiome pattern reflects healthy ageing and predicts survival in humans

Increasing compositional uniqueness of the gut microbiome, and corresponding changes in microbial metabolites in the blood, are identified as a signature of healthy ageing in humans.

Tomasz Wilmanski
Christian Diener
Nathan D. Price
Research18 Feb 2021
Nature Metabolism

Volume: 3, P: 274-286
The geometry of clinical labs and wellness states from deeply phenotyped humans

Longitudinal multi-omics measurements are highly valuable in studying heterogeneity in health and disease phenotypes. Here, the authors apply Pareto Task Inference to analyze the clinical lab tests of 3094 individuals and find three wellness states, and one aberrant health state defining this cohort.

Anat Zimmer
Yael Korem
Nathan D. Price
ResearchOpen Access11 Jun 2021
Nature Communications

Volume: 12, P: 1-13
Health and disease markers correlate with gut microbiome composition across thousands of people

Variation in the gut microbiome can reflect host lifestyle, behaviour, and influence blood-based biomarkers. Here the authors examine associations between the microbiota and 150 host phenotypic features in a large cohort of >3,000 individuals.

Ohad Manor
Chengzhen L. Dai
Andrew T. Magis
ResearchOpen Access15 Oct 2020
Nature Communications

Volume: 11, P: 1-12
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and H4, and use the collection to study of the role of PMTs in mouse and human T cell differentiation.

Sebastian Scheer
Suzanne Ackloo
Cheryl H. Arrowsmith
ResearchOpen Access03 Jan 2019
Nature Communications

Volume: 10, P: 1-14
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiating cells, and can be targeted by EZH2 inhibition

Evelyne Lima-Fernandes
Alex Murison
Catherine A. O’Brien
ResearchOpen Access29 Mar 2019
Nature Communications

Volume: 10, P: 1-14
Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis

Andrew T. Magis
Noa Rappaport
Nathan D. Price
ResearchOpen Access01 Oct 2020
Scientific Reports

Volume: 10, P: 1-6
Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation

Richter’s Transformation is a treatment-resistant and fatal progression from Chronic Lymphocytic Leukemia (CLL) to an aggressive lymphoma. Here, the authors show that PRMT5 is upregulated months prior to and after transformation, PRMT5 overexpression in a CLL mouse model leads to increased risk of transformation, and that targeted PRMT5 inhibition prolongs survival and delays disease development.

Zachary A. Hing
Janek S. Walker
Rosa Lapalombella
ResearchOpen Access06 Jan 2023
Nature Communications

Volume: 14, P: 1-21
Reply to "Precision medicine in the clouds"

Andrew T Magis
John C Earls
Leroy Hood
Correspondence06 Aug 2018
Nature Biotechnology

Volume: 36, P: 680-682
Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program

Niha Zubair
Matthew P. Conomos
Jennifer C. Lovejoy
ResearchOpen Access02 May 2019
Scientific Reports

Volume: 9, P: 1-11
Geno4ME Study: implementation of whole genome sequencing for population screening in a large healthcare system

Isabelle A. Lucas Beckett
Kate R. Emery
Ora K. Gordon
ResearchOpen Access01 Jul 2025
npj Genomic Medicine

Volume: 10, P: 1-15
The transition from genomics to phenomics in personalized population health

This Perspective reviews large-scale genomics and longitudinal phenomics efforts and the insights they can provide into wellness. The authors describe their vision for the transformation of the current health care from disease-oriented to data-driven, wellness-oriented and personalized population health.

James T. Yurkovich
Simon J. Evans
Leroy E. Hood
Reviews13 Dec 2023
Nature Reviews Genetics

Volume: 25, P: 286-302
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Laura Heath
John C. Earls
Yi Zhao
ResearchOpen Access12 Apr 2022
Scientific Reports

Volume: 12, P: 1-17
An unfortunate resurgence of human chorionic gonadotropin use for weight loss

J C Lovejoy
M Sasagawa
Comments & Opinion04 Oct 2011
International Journal of Obesity

Volume: 36, P: 385-386

Search

Crystal structure of the DsbA protein required for disulphide bond formation in vivo

Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention

Stress responses in an Arctic microalga (Pelagophyceae) following sudden salinity change revealed by gene expression analysis

Author Correction: Gut microbiome pattern reflects healthy ageing and predicts survival in humans

A wellness study of 108 individuals using personal, dense, dynamic data clouds

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Blood metabolome predicts gut microbiome α-diversity in humans

Gut microbiome pattern reflects healthy ageing and predicts survival in humans

The geometry of clinical labs and wellness states from deeply phenotyped humans

Health and disease markers correlate with gut microbiome composition across thousands of people

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis

Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation

Reply to "Precision medicine in the clouds"

Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program

Geno4ME Study: implementation of whole genome sequencing for population screening in a large healthcare system

The transition from genomics to phenomics in personalized population health

Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

An unfortunate resurgence of human chorionic gonadotropin use for weight loss

Search

Quick links

Search

Filter By:

Search

Quick links