Nature Search

Distinct gastrointestinal microbial signatures predict parasite levels in controlled Plasmodium infections in both rhesus macaques and humans

Here, the authors show that pre-infection gastrointestinal microbial composition predicts parasite levels in rhesus macaques infected with P. fragile and humans infected with P. falciparum in a controlled human malaria infection (CHMI) study.

Andrew T. Gustin
Courtney A. Broedlow
Jennifer A. Manuzak
ResearchOpen Access19 Dec 2025
Nature Communications

Volume: 17, P: 1-18
Factors Influencing Survival in Carcinoma of the Ovary

Jennifer L Dyson
J O W Beilby
S J Steele
Research01 Jun 1971
British Journal of Cancer

Volume: 25, P: 237-249
Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer

A randomized phase 2 clinical trial has recently shown no benefit of the combination eribulin and pembrolizumab over pembrolizumab alone in HR + metastatic breast cancer patients (NCT03051659). Here, the authors are reporting the final OS data and biomarker analyses on a subset of samples to analyze molecular correlates

Tanya E. Keenan
Jennifer L. Guerriero
Sara M. Tolaney
ResearchOpen Access21 Sept 2021
Nature Communications

Volume: 12, P: 1-13
Programs, origins and immunomodulatory functions of myeloid cells in glioma

A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell types, driven by microenvironmental cues and predictive of therapeutic response.

Tyler E. Miller
Chadi A. El Farran
Bradley E. Bernstein
ResearchOpen Access26 Feb 2025
Nature

Volume: 640, P: 1072-1082
Quality control for single-cell analysis of high-plex tissue profiles using CyLinter

Microscopy artifacts and tissue imperfections interfere with single-cell analysis. CyLinter software offers quality control for high-plex tissue profiling by removing artifactual cells, thereby facilitating accuracy of biological interpretation.

Gregory J. Baker
Edward Novikov
Peter K. Sorger
ResearchOpen Access30 Oct 2024
Nature Methods

Volume: 21, P: 2248-2259
RETRACTED ARTICLE: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Polymerase (POL) θ inhibitors display synthetic lethality in tumours with homologous recombination repair deficiency. Here, the authors demonstrate that POLθ inhibition with novobiocin activates the cGAS/STING pathway in BRCA-deficient cancers.

Jeffrey Patterson-Fortin
Heta Jadhav
Geoffrey I. Shapiro
ResearchOpen Access13 Mar 2023
Nature Communications

Volume: 14, P: 1-16
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer

Mehta et al. show that PARP inhibition induces CSF1R-dependent immune-suppressive macrophages, and that its blockade restores PARP inhibitor efficacy and stimulates CD8⁺ T cell-dependent antitumor immunity in triple-negative breast cancer.

Anita K. Mehta
Emily M. Cheney
Jennifer L. Guerriero
Research14 Dec 2020
Nature Cancer

Volume: 2, P: 66-82
Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer

Jennifer L. Guerriero
Jia-Ren Lin
Sandro Santagata
ResearchOpen Access02 Jan 2024
npj Breast Cancer

Volume: 10, P: 1-22
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

Results from a phase 3, double-blind, randomized, placebo-controlled trial demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder.

Jennifer M. Mitchell
Michael Bogenschutz
Rick Doblin
ResearchOpen Access10 May 2021
Nature Medicine

Volume: 27, P: 1025-1033
Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma

Ghobrial, Getz and colleagues characterize the changes in the tumor immune microenvironment associated with multiple myeloma progression.

Oksana Zavidij
Nicholas J. Haradhvala
Irene M. Ghobrial
Research27 Apr 2020
Nature Cancer

Volume: 1, P: 493-506
Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Jeffrey Patterson-Fortin
Heta Jadhav
Geoffrey I. Shapiro
Amendments and CorrectionsOpen Access11 Dec 2023
Nature Communications

Volume: 14, P: 1
SIGLEC9 tips the myeloid balance in glioblastoma

Glioblastoma is an aggressive brain tumor with a highly immunosuppressive environment that responds poorly to immune checkpoint inhibitors. A study shows that SIGLEC9⁺ monocyte-derived macrophages are enriched in glioblastomas that do not respond to immune checkpoint inhibitors, and targeting this receptor synergizes with immunotherapy.

Thomas U. Marron
Jennifer L. Guerriero
News & Views27 Jul 2023
Nature Cancer

Volume: 4, P: 1217-1219
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

A selective class IIa histone deacetylase inhibitor induces anti-tumour immunity in a mouse model of mammary cancer through altered differentiation and recruitment of tumour-associated macrophages.

Jennifer L. Guerriero
Alaba Sotayo
Anthony Letai
Research08 Mar 2017
Nature

Volume: 543, P: 428-432
Genomic evolution and chemoresistance in germ-cell tumours

Genomic analyses show that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, mutations in KRAS and have high mitochondrial priming, providing insight into chemosensitivity and the evolution of chemoresistance in this disease.

Amaro Taylor-Weiner
Travis Zack
Eliezer M Van Allen
Research30 Nov 2016
Nature

Volume: 540, P: 114-118
STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer

Constantia Pantelidou
Heta Jadhav
Geoffrey I. Shapiro
ResearchOpen Access06 Sept 2022
npj Breast Cancer

Volume: 8, P: 1-6
MITI minimum information guidelines for highly multiplexed tissue images

The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology.

Denis Schapiro
Clarence Yapp
Peter K. Sorger
Comments & Opinion11 Mar 2022
Nature Methods

Volume: 19, P: 262-267

Search

Distinct gastrointestinal microbial signatures predict parasite levels in controlled Plasmodium infections in both rhesus macaques and humans

Factors Influencing Survival in Carcinoma of the Ovary

Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer

Programs, origins and immunomodulatory functions of myeloid cells in glioma

Quality control for single-cell analysis of high-plex tissue profiles using CyLinter

RETRACTED ARTICLE: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer

Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma

Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

SIGLEC9 tips the myeloid balance in glioblastoma

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

Genomic evolution and chemoresistance in germ-cell tumours

STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer

MITI minimum information guidelines for highly multiplexed tissue images

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