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Showing 1–20 of 20 results
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  • Using a new analytical method for tracking gamma band events in mouse visual cortex, flexible encoding of visual information according to behavioural context is shown.

    • Quentin Perrenoud
    • Antonio H. de O. Fonseca
    • Jessica A. Cardin
    ResearchOpen Access
    Nature
    Volume: 647, P: 962-969

  • The early postnatal roles of dendrite-targeting interneurons in primary visual cortex (V1) remain elusive. Here, the authors find that somatostatin interneurons in mouse V1 exhibit a uniquely delayed developmental trajectory for innervation and sensory responses, highlighting a window for the emergence of a key mechanism for normalization in cortical circuits.

    • Alex Wang
    • Katie A. Ferguson
    • Jessica A. Cardin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • On the anniversary of the Boyden et al. (2005) paper that introduced the use of channelrhodopsin in neurons, Nature Neuroscience asks selected members of the community to comment on the utility, impact and future of this important technique.

    • Antoine Adamantidis
    • Silvia Arber
    • Rachel I Wilson
    Comments & Opinion
    Nature Neuroscience
    Volume: 18, P: 1202-1212

  • Cortical gamma oscillations (20–80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease; however, what induces this activity band is unclear. Here, by using a cell-type targeted optogenetic approach, it is revealed that gamma oscillations can be driven by specific activation of fast-spiking interneurons in vivo, and that sensory input relative to these oscillations can determine the extent of evoked cortical activity.

    • Jessica A. Cardin
    • Marie Carlén
    • Christopher I. Moore
    Research
    Nature
    Volume: 459, P: 663-667

  • Using dual-color mesoscopic imaging in the neocortex of awake mice, the authors show that cholinergic release and neuronal activity exhibit distinct spatiotemporal patterns that are differentially linked to spontaneous fluctuations in behavioral state.

    • Sweyta Lohani
    • Andrew H. Moberly
    • Jessica A. Cardin
    Research
    Nature Neuroscience
    Volume: 25, P: 1706-1713

  • Orientation selectivity in visual cortex is not simply the result of linear input summation. Instead, selectivity is enhanced by nonlinear dendritic transformation of spatially clustered, cotuned synaptic inputs.

    • Jessica A Cardin
    News & Views
    Nature Neuroscience
    Volume: 19, P: 984-986

  • Changes in cortical gain enable neurons to respond adaptively to changing inputs. In this Review, Ferguson and Cardin describe the mechanisms that modulate cortical gain, and its effects on and relevance for cognition and behaviour.

    • Katie A. Ferguson
    • Jessica A. Cardin
    Reviews
    Nature Reviews Neuroscience
    Volume: 21, P: 80-92

  • The Cousa objective is an ultra-long working distance air objective optimized for two- and three-photon imaging. Bypassing challenges caused by water immersion and short working distances, the Cousa enables and improves imaging of diverse specimens.

    • Che-Hang Yu
    • Yiyi Yu
    • Spencer LaVere Smith
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 132-141

  • Integral equations are used in science and engineering to model complex systems with non-local dependencies; however, existing traditional and machine-learning-based methods cannot yield accurate or efficient solutions in several complex cases. Zappala and colleagues introduce a neural-network-based method that can learn an integral operator and its dynamics from data, demonstrating higher accuracy or scalability compared with several state-of-the-art methods.

    • Emanuele Zappala
    • Antonio Henrique de Oliveira Fonseca
    • David van Dijk
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 6, P: 1046-1062

  • A consortium reports the tripling of the number of genetic markers in Phase II of the International HapMap Project. This map of human genetic variation will continue to revolutionize discovery of susceptibility loci in common genetic diseases, and study of genes under selection in humans.

    • Kelly A. Frazer (Principal Investigator)
    • Dennis G. Ballinger
    • John Stewart
    Research
    Nature
    Volume: 449, P: 851-861

  • In this Technical Report, Chuong and colleagues introduce Jaws, an archaeon-derived, photoactivatable chloride pump that responds to red light. Owing to its efficiency in absorbing red photons and its large photocurrent, Jaws can be transcranially activated deep in the brain and thus allows noninvasive optogenetic silencing.

    • Amy S Chuong
    • Mitra L Miri
    • Edward S Boyden
    Research
    Nature Neuroscience
    Volume: 17, P: 1123-1129

  • Sabeti et al. build on their This paper builds on previous work of detecting selection on human genes, using the many more markers available in the Phase II HapMap project. Three examples of apparent population-specific selection based on geographic area are described, and how these may relate to human biology is discussed.

    • Pardis C. Sabeti
    • Patrick Varilly
    • John Stewart
    Research
    Nature
    Volume: 449, P: 913-918