Nature Search

A cognitive layer architecture to support large-language model performance in psychotherapy interactions

A real-world study showed that introducing a cognitive layer architecture to support specialized psychotherapeutic reasoning capabilities in general-purpose chatbots improved depression and anxiety symptoms compared to chatbots or therapists alone.

Max Rollwage
Jessica McFadyen
Ross Harper
Research12 Mar 2026
Nature Medicine

P: 1-9
Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT)

McFadyen et al. test whether a generative AI-powered app could improve engagement with self-help cognitive behavioral therapy compared with digital workbooks. The AI app was used more often and for longer, with similar effectiveness, suggesting it can enhance engagement in digital mental health care.

Jessica McFadyen
Johanna Habicht
Max Rollwage
ResearchOpen Access15 Jan 2026
Communications Medicine

Volume: 6, P: 1-14
Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy

A red blood cell haemostatic mechanism induced by dying ECs functions independently of platelets and fibrin.

Mike C. L. Wu
Ethan Italiano
Shaun P. Jackson
Research04 Jun 2025
Nature

Volume: 643, P: 182-191
Differential replay of reward and punishment paths predicts approach and avoidance

During planning, the brain rapidly activates memories of paths leading to reward or punishment. In a new MEG study, the authors show that choosing to approach under uncertainty evokes reactivation of potential punishment, while avoiding reactivates forgone rewards.

Jessica McFadyen
Yunzhe Liu
Raymond J. Dolan
Research05 Apr 2023
Nature Neuroscience

Volume: 26, P: 627-637
The influence of subcortical shortcuts on disordered sensory and cognitive processing

Early processing in subcortical areas has been underemphasized in models of how perception and cognition are altered in psychiatric disorders. Here, McFadyen and colleagues review recent discoveries in how subcortical–cortical dynamics contribute to perception and higher-order cognition.

Jessica McFadyen
Raymond J. Dolan
Marta I. Garrido
Reviews08 Apr 2020
Nature Reviews Neuroscience

Volume: 21, P: 264-276
The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function

The lipid kinase PI3KC2α is essential for embryogenesis, yet its role in adult homeostasis is unknown. Here, the authors show that PI3KC2α regulates the structure of the internal membrane reserves of murine megakaryocytes and platelets, affecting the platelets’ adhesiveness and prothrombotic function.

Jessica K. Mountford
Claire Petitjean
Shaun P. Jackson
Research17 Mar 2015
Nature Communications

Volume: 6, P: 1-14
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12

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A cognitive layer architecture to support large-language model performance in psychotherapy interactions

Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT)

Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy

Differential replay of reward and punishment paths predicts approach and avoidance

The influence of subcortical shortcuts on disordered sensory and cognitive processing

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function

Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

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