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Showing 1–3 of 3 results
Advanced filters: Author: Jesslyn E. Park Clear advanced filters

  • Modular synthesis and structural biology are used to design and characterize group A streptogramin antibiotics, one of which has activity against streptogramin-resistant strains and demonstrates efficacy in a mouse model of bacterial infection.

    • Qi Li
    • Jenna Pellegrino
    • Ian B. Seiple
    Research
    Nature
    Volume: 586, P: 145-150

  • Stochastic fluctuations at the transcriptional level contribute to heterogeneity in isogenic cell populations. Here, the authors engineer TuNR which modulates the variability in gene expression of endogenous human genes independent of their mean expression.

    • Alain R. Bonny
    • João Pedro Fonseca
    • Hana El-Samad
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Two de novo designed protein classes that link phosphorylation by tyrosine and serine kinases to protein-protein association provide potential new avenues to regulating cell function.

    • Nicholas B. Woodall
    • Zara Weinberg
    • David Baker
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 762-770