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Showing 1–8 of 8 results
Advanced filters: Author: Jesus M. Gomez-Salinero Clear advanced filters

  • Gomez-Salinero, Itkin et al. demonstrate the cooperative role of two ETS transcriptor factors, ERG and Fli1, in the active maintenance of endothelial cell homeostatic function. Loss of these two genes in adult mice leads to multi-organ failure, hyperinflammation, systemic thrombosis and death. In vitro, expression of both ERG and FLI1 induces human adult non-vascular mesenchymal stromal cells to acquire endothelial-like properties. In humans, several cardiovascular disorders and inflammatory-related diseases are linked to mutations in both genes.

    • Jesus M. Gomez-Salinero
    • Tomer Itkin
    • Shahin Rafii
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 882-899

  • Itkin et al. identify a role for Fli-1 in hematopoietic stem cell activation during regenerative hematopoiesis. They show that Fli-1 coordinates hematopoietic stem cells to stimulate niche-derived Notch1 feedback signals for demand-needed hematopoietic cell output.

    • Tomer Itkin
    • Sean Houghton
    • Shahin Rafii
    Research
    Nature Immunology
    Volume: 26, P: 378-390

  • The pancreatic vasculature displays significant heterogeneity, with the islets perfused by a specialized microcirculation with greater density than the surrounding acinar tissue. Using single-cell RNA sequencing of human pancreases and integration with further data, the authors reveal the vascular transcriptomic heterogeneity in the healthy and diabetic pancreas.

    • Rebecca Craig-Schapiro
    • Ge Li
    • David Redmond
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The transient reactivation of ETV2 in adult human endothelial cells reprograms these cells to become adaptable vasculogenic endothelia that in three-dimensional matrices self-assemble into vascular networks that can transport blood and physiologically arborize organoids and decellularized tissues.

    • Brisa Palikuqi
    • Duc-Huy T. Nguyen
    • Shahin Rafii
    Research
    Nature
    Volume: 585, P: 426-432

  • The kidney is vascularized with highly specialized and zonated endothelial cells that are essential for its filtration function. Here, Barry et al. provide a single-cell RNA sequencing analysis of the kidney vasculature that highlights its transcriptional heterogeneity and uncovers pathways important for its development and function.

    • David M. Barry
    • Elizabeth A. McMillan
    • Shahin Rafii
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Vascular patterning is dictated by transcription factors, such as the Notch pathway. Molecular profiling has uncovered snapshots of the transcriptional specification of endothelial cell tubulogenesis. Here, the authors leverage the output of Notch signaling, demonstrating that vascular remodeling is poorly predicted by transcriptional profiling.

    • Jesus M. Gomez-Salinero
    • Shahin Rafii
    News & Views
    Nature Cardiovascular Research
    Volume: 2, P: 492-493

  • Endothelial cells (ECs) undergo organ-specific specialization, driven by microenvironmental cues, to form patterned vascular networks. This article discusses mechanisms driving vascular inter-organ and intra-organ EC heterogeneity, crosstalk between ECs and neighbouring cells, and the therapeutic potential of engineering ECs.

    • Jesus M. Gomez-Salinero
    • David Redmond
    • Shahin Rafii
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 476-495