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Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A

This study identifies NAT10-mediated RNA ac4C modification as a key regulator of colonic epithelial aging. Through N4-acetylation regulation of DYRK1A, NAT10 promotes intestinal senescence, highlighting a potential therapeutic target for elderly-onset colitis.

Jingyu Chen
Meng Xue
Shujie Chen
ResearchOpen Access01 Mar 2026
Nature Communications

P: 1-17
Combination of Human Fas (CD95/Apo-1) Ligand with Adriamycin Significantly Enhances the Efficacy of Antitumor Response

Zhongchen Liu
Ruizhen Liu
Guohong Zhuang
Research01 Jun 2009
Cellular & Molecular Immunology

Volume: 6, P: 167-174
Adaptive amino acid substitutions enable transmission of an H9N2 avian influenza virus in guinea pigs

Liu Lina
Chen Saijuan
Zhao Zongzheng
ResearchOpen Access24 Dec 2019
Scientific Reports

Volume: 9, P: 1-8

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Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A

Combination of Human Fas (CD95/Apo-1) Ligand with Adriamycin Significantly Enhances the Efficacy of Antitumor Response

Adaptive amino acid substitutions enable transmission of an H9N2 avian influenza virus in guinea pigs

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