C-terminal peptide salicylaldehyde ester synthesis is a challenge due to intrinsic epimerization. Now the development of epimerization-free synthesis of peptide C-terminal salicylaldehyde esters is reported. The approach uses side-chain-protected peptides, formed through solid-phase synthesis, and 2-(dichloromethyl)phenol as substrates and proceeds through an O-to-O acyl transfer process.
- Wang Xia
- Bing-Wen Li
- Xuechen Li
