Through sequencing of 88,005 nuclei from the breast tissues of clinically healthy women of diverse genetic ancestry, a global breast single-nucleus atlas was developed that identifies distinct cell types and ancestry-level differences linked to epithelial and fibroblast cell states, which in turn could influence disease incidence, molecular subtypes and progression.
- Poornima Bhat-Nakshatri
- Hongyu Gao
- Harikrishna Nakshatri
