In this work, we prepared a composite hydrogel system of PDA-HA hydrogel-loaded CaO2-ICG@LA@MnO2 nanoparticles that showed excellent photothermal performance under NIR irradiation and realized the on-off release of oxygen and ROS. Controllable and sustainable oxygen release can promote the regeneration and repair of damaged tissue, and the generated ROS can effectively inhibit the outbreak of inflammation at the initial stage of wound healing. A full-thickness skin defect repair test was carried out in rats with the prepared hydrogel wound dressings and the results showed that hydrogel + NIR group had the most wound healing effective.
- Chunyang Li
- Xiaojun He
- Deyan He