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Conserved and divergent gene regulatory networks for crop drought resistance

Deng et al. leverage AI and large-scale transcriptome data to map drought-response gene networks, uncovering conserved and lineage-specific regulatory patterns, and revealing that drought resistance is shaped by network architecture, not only individual genes.

Xianzhi Deng
Liangsheng Shi
Xiaolong Hu
ResearchOpen Access17 Apr 2026
Nature Communications

P: 1-21
Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis

Here, the authors show that Msx2 deficiency prevents osteoclast fusion and enhances type H vessel- mediated osteogenesis. Mechanically, MSX2 protects PU.1 from FBXW7 mediated degradation and targeting Msx2 serves as an anabolic therapy in pre-clinical models of osteoporosis.

Qingliang Ma
Shiyu Wang
Zhiwei Jie
ResearchOpen Access06 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

Host defense against helminth infection is mediated by mucosal type 2 immunity. Using gain- and loss-of-function mouse models, and mouse intestinal organoids, Xiong et al. show that SIRT6 modulates tuft and goblet cell expansion in intestinal epithelium by activating STAT6 to maintain type 2 mucosal immunity in response to helminth infection.

Xiwen Xiong
Chenyan Yang
Qingzhi Wang
ResearchOpen Access03 Sept 2022
Nature Communications

Volume: 13, P: 1-16
Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network

During zygotic genome activation the embryo must re-wire the regulatory network that sustains totipotency earlier during development. Here they identify ZFP352 as an essential factor that targets retrotransposon families to facilitate dissolution of the totipotency network and enable ZGA.

Zhengyi Li
Haiyan Xu
Hongqing Liang
ResearchOpen Access20 Jun 2023
Nature Communications

Volume: 14, P: 1-16
Association of myosteatosis with short-term outcomes in patients with acute-on-chronic liver failure

Nan Geng
Ming Kong
Zhongping Duan
ResearchOpen Access13 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Attenuated Salmonella carrying siRNA-PD-L1 and radiation combinatorial therapy induces tumor regression on HCC through T cell-mediated immuno-enhancement

Huijie Jia
Pengkun Wei
Tiesuo Zhao
ResearchOpen Access28 Aug 2023
Cell Death Discovery

Volume: 9, P: 1-9
FMR1 promotes the progression of colorectal cancer cell by stabilizing EGFR mRNA in an m⁶A-dependent manner

Yuhan Hu
Qingzu Gao
Jiateng Zhong
ResearchOpen Access08 Nov 2022
Cell Death & Disease

Volume: 13, P: 1-14
Mediating oxidative stress through the Palbociclib/miR-141-3p/STAT4 axis in osteoporosis: a bioinformatics and experimental validation study

Jiajia Ji
Shaobo Wu
Dageng Huang
ResearchOpen Access10 Nov 2023
Scientific Reports

Volume: 13, P: 1-16

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Conserved and divergent gene regulatory networks for crop drought resistance

Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis

Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network

Association of myosteatosis with short-term outcomes in patients with acute-on-chronic liver failure

Attenuated Salmonella carrying siRNA-PD-L1 and radiation combinatorial therapy induces tumor regression on HCC through T cell-mediated immuno-enhancement

FMR1 promotes the progression of colorectal cancer cell by stabilizing EGFR mRNA in an m⁶A-dependent manner

Mediating oxidative stress through the Palbociclib/miR-141-3p/STAT4 axis in osteoporosis: a bioinformatics and experimental validation study

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