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Advanced filters: Author: Jingjiao Zhou Clear advanced filters

Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance

PDLIM2 is repressed epigenetically in lung cancers, which are frequently resistant to anti-PD-1/PD-L1 and chemotherapy. Here, the authors describe the mechanism through which epigenetic restoration of PDLIM2 synergises with anti-PD-1 and chemotherapy in lung cancers.

Fan Sun
Liwen Li
Zhaoxia Qu
ResearchOpen Access22 Nov 2019
Nature Communications

Volume: 10, P: 1-13
FPR1 signaling aberrantly regulates S100A8/A9 production by CD14⁺FCN1^hi macrophages and aggravates pulmonary pathology in severe COVID-19

CD14⁺FCN1^hi macrophages highly express S100A8/S100A9, which is initiated by FPR1 signaling in severe COVID-19. An FPR1 inhibitor prevents the transcription, hetero-dimerization, and secretion of S100A8/A9 through STAT3/PLC-γ/ERK1/2 pathways.

Zhongyi Wang
Yi Wang
Jingjiao Zhou
ResearchOpen Access14 Oct 2024
Communications Biology

Volume: 7, P: 1-14
The third-generation anti-CD30 CAR T-cells specifically homing to the tumor and mediating powerful antitumor activity

Shangkun Zhang
Chaojiang Gu
Tongcun Zhang
ResearchOpen Access21 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells

Liqing Song
Xuegang Yuan
Yan Li
ResearchOpen Access30 Jul 2019
Scientific Reports

Volume: 9, P: 1-18
Different antiviral effects of IFNα subtypes in a mouse model of HBV infection

Jingjiao Song
Sheng Li
Kathrin Sutter
ResearchOpen Access23 Mar 2017
Scientific Reports

Volume: 7, P: 1-13