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Showing 1–3 of 3 results
Advanced filters: Author: Jingpei Shi Clear advanced filters

  • Alternative splicing at the Drosophila Down syndrome cell adhesion molecule gene generates 38,016 isoforms, and underlies self-avoidance of growing neurons. Wang et al. identify a structure in the DSCAM mRNA that ensures mutually exclusive splicing and observe expansion of the structure with increasing number of exons during arthropod evolution.

    • Xuebin Wang
    • Guoli Li
    • Yongfeng Jin
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-11

  • Alternative splicing plays a major role in the generation of functional diversity but the underlying mechanisms remain poorly understood. In a comparative genome analysis of 73 arthropod species, spanning around 420 million years of evolution, Yongfeng and coworkers find built-in intronic elements that lead to mutual exclusive splicing. These elements are species- or clade-specific, but evolutionarily conserved at the secondary structure level.

    • Yun Yang
    • Leilei Zhan
    • Yongfeng Jin
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 159-168