The treatment of lung cancer with checkpoint inhibitors is limited by the emergence of complications, including immunotherapy-induced pneumonitis (CIP). However, the immunological changes accompanying CIP are poorly characterized. Here, the authors perform single-cell analysis of CIP samples isolated from lung cancer patients and identify IFNγ-producing CD8 Tissue-resident T cells, IgG isotype class switching in B cells, and GSDME-mediated macrophage pyroptosis as central players in CIP.
- Xinqing Lin
- Chunjie Li
- Chengzhi Zhou
