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This study reports on an AI-powered autonomous experimentation platform that overcomes data scarcity in electronic materials discovery by using an AI advisor for real-time progress monitoring, data analysis and interactive human–AI collaboration. Applied to mixed ion–electron conducting polymers, it rapidly optimized performance in 64 experimental trials, revealing morphology–property relationships and an unreported polymer polymorph.

A general two-step intercalation and cation-exchange strategy is used to produce a library of highly ordered magnetic intercalation superlattices with tunable chemical modulations and magnetic ordering.

A chemical dedoping technique is introduced to mitigate excessive electron doping in molecular cation intercalated MoS₂, producing a stable bulk monolayer material with monolayer-like optical properties but a much larger optical cross-section.

Elastocaloric cooling is a promising alternative to conventional vapour-compression systems, but greater cooling power is needed for practical use. Now, a series of design optimizations have produced an elastocaloric system delivering kilowatt-scale cooling power, a milestone towards practical solid-state cooling.

Zhou et al. present a multivariate GWAS on pubertal timing, identifying 18 novel variants. The results suggest associations of earlier puberty with accelerated ageing and higher risks of cardiovascular disease and osteoporosis.

SFTS is an emerging tick-borne disease with high mortality rates caused by the SFTS virus. Here, the authors identify LRP1 as an entry factor for SFTSV, show that SFTSV glycoprotein Gn interacts with LRP1 and that blocking LRP1 reduces viral infection and improves survival in lethal mouse models.

Invasive early stage lung adenocarcinoma has a heterogeneous prognosis. Here, the authors microdissect malignant pulmonary nodules to invasive and preinvasive components and study the mutations that are common or private between the lesions, allowing them to understand the evolutionary path of the tumours.

Exploring intrinsic sliding ferroelectric semiconductors without artificial stacking or chemical modification is crucial. Here, the authors report a naturally parallel-stacked ReSe₂ sliding ferroelectric semiconductor through a rational sliding approach.

Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the NFKB1 and IRF4 genes and additional ancestry-specific effects.

Anlotinib hydrochloride is a multi-target tyrosine kinase receptor inhibitor, previously combined with anti-PD1 as therapeutic strategy for several cancer types. Here the authors report the results of a phase II trial of nivolumab (anti-PD1) plus anlotinib hydrochloride in patients with advanced gastric adenocarcinoma and esophageal squamous cell carcinoma.

Most sunlight received by photovoltaic panels is converted to and lost as heat, increasing their temperature and deteriorating their performance. Here, the authors propose a multi-energy generation photovoltaic leaf concept with biomimetic transpiration and demonstrate much improved performance.

Phage immunoprecipitation sequencing illustrates the wide breadth of systemic microbiota-specific antibody responses, which are more longitudinally stable than gut microbiome species abundances in a cohort of healthy individuals.

Ganoderma lucidumis a macrofungus in traditional Chinese medicine known to produce different bioactive compounds. In this study, the genome ofG. lucidumis sequenced, making this organism a potential model system for future studies of secondary metabolic pathways and their regulation in medicinal fungi.

Hypoxia is associated with metastasis and mortality. Here, the authors show that intratumoral hypoxia is linked to oxidative stress driving both HIF and NF-kB signaling to sustain a ROS-resistant phenotype that drives metastasis partially via MUC1-C.

Genome-wide association analyses identify 30 risk loci for IgA nephropathy. Functional annotations of putative causal genes converge on inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.

Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.

Water condensation on surfaces occurs in nature everywhere, but the study of its initial stage at ambient conditions is very challenging. Here, Song et al.address this issue using thermal controlled atomic force microscopy and identify a mixture of layer-by-layer and island-like modes.

Screening in Escherichia coli and biochemical experiments show that in Arabidopsis thaliana, OSCA2.1 and OSCA2.2 function as plant sensors of hypo-osmolarity, utilize Ca²⁺ oscillations as second messengers and have crucial roles in pollen germination.

By incorporating chiral molecules into conventional superconductor lattices such as TaS₂ to form a hybrid superlattice, non-centrosymmetry could be introduced and can be shown to help lead to unconventional superconductivity.

LncRNAs modulate diverse physiological cellular processes, however, their involvement in heme-dependent processes are not yet clear. Here the authors reveal the role of lncRNA UCA1 in erythroid cell development.

Here, Ning et al report the cellular interactomes of Crimean-Congo haemorrhagic fever virus glycoproteins and uncover a host restriction factor HAX1 that hijacks the viral glycoproteins to mitochondria, disabling progeny virion packaging.

While platinum is a highly active catalyst for H₂ evolution, its low abundance prompts research into earth-abundant alternatives. Here, authors prepare tungsten atomic clusters on phosphorus doped carbon by thermal migration and demonstrate excellent activities for hydrogen evolution electrocatalysis.

A type II supernova (SN 2023ixf) was observed in the galaxy M101 at a distance of 6.85  ±  0.15 Mpc, at about 1.0  h after the explosion.

A study using a copper-in-silver dilute alloy catalyst in a high-pressure gas flow reactor reports highly selective electrosynthesis of acetate from carbon monoxide.

A simple spectral selective active colloidal system is designed in which TiO₂ colloidal species are coded with dyes to form a photochromic swarm that adapts the appearance of incident light due to layered phase segregation.

A one-step simultaneous van der Waals integration of high-k dielectrics and contacts enables the realization of top-gated transistors with atomically clean and electronically sharp interfaces.

A van der Waals contact approach enables the observation of photocarrier-induced persistent structural polarization in lead halide perovskites.

Covalent organic framework-based membranes are highly tunable materials with potential use in a variety of applications. Here the authors report a dual-activation interfacial polymerization strategy to prepare ionic covalent organic framework membranes with high ion exchange capacity.

While single-atom catalysis offers an efficient materials usage, the ambiguous interactions with supports poses a difficulty in understanding catalytic performances. Here, authors show an ensemble effect via synergy of Co adatoms and the S of MoS₂ supports to boost hydrogen evolution activities.

In situ tuning of the electronic structure of active sites is a long-standing challenge. Here, the authors report an approach to tune the electronic structure of cobalt species during the styrene epoxidation reaction by the introduction of controllable hydrogen spillover for enhanced selectivity.

This Perspective discusses the analytical issues concerning heterogeneity and power encountered in microbial genome-wide association studies and highlights potential future directions for genetic analysis of the microbiome.

A plant species identification method, GAGE, is reported that searches for target sequences from the whole genome of the subject plant and specifically detects them by employing a CRISPR/Cas12a system.