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A bonding and debonding strategy is used to stack epitaxially grown semiconductor monolayers into various structures with precise control of the layer number and interlayer twist angle.

High-quality genome sequence of cultivated peanut comprising 2.54 Gb with 20 pseudomolecules and 83,709 protein-coding gene models provides insights into genome evolution and the genetic mechanisms underlying seed size and leaf resistance in peanut.

This study identifies the TaDT1-A^hapI allele conferring drought resistance without yield penalty. Its 899-bp promoter deletion evades TaMYC2 repression and thereby enhances autophagy-mediated stomatal dynamics and water-use efficiency, providing a potential breeding target.

A new donkey reference genome and comparisons with wild asses yields insights into the evolutionary history of donkey domestication and identifies a genetic variant that results in the non-Dun coat colours of domestic donkeys.

Deletion of upstream tumor suppressors of the Hippo/YAP pathway is frequent in papillary renal cell carcinoma (pRCC). Here, the authors employ a transgenic mouse model, single-cell transcriptomics and public genomic datasets to show that targeting hyperactivated YAP1 prevents neoplastic renal epithelial cell immune evasion and impairs the development of pRCC.

Mulberry trees are the primary food source for silkworms, which are reared for the production of silk. In this study, He et al. present the draft genome sequence of Morus notabilisand find that it evolved significantly faster than other plants in the Rosales order.

In this work, the authors report Cryo-EM structures of the signaling complexes of human GPR21, an orphan GPCR and a potential metabolic disease target, and reveal unique receptor activation conformation when bound to downstream signaling proteins in the absence of any ligand.

A high-quality genome of Aristolochia fimbriata illuminates its unique history of whole-genome duplication similar to Amborella, the genomic basis of its complex flower morphology and chemical biosynthesis, and the phylogenetic placement of magnoliids.

An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies.

Here, the authors report structures of corticotropin releasing factor receptor 2 (CRF2R) bound to agonist Urocortin 1 (UCN1) and coupled to G proteins G₁₁ and G_o, offering insight into the structural basis for the ability of CRF2R to couple with multiple G protein subtypes.

The application of 2D MoS₂ flexible integrated circuits (ICs) is currently limited by the material quality over large areas and the device fabrication technology. Here the authors report a gate-first fabrication technique to realize wafer-scale monolayer MoS₂ ICs on rigid and flexible substrates with high performance and low power consumption.

A cryogenic electron microcopy study of structures of a human receptor for bitter taste finds that cholesterol can activate the receptor, while the tastant molecule acts allosterically on the receptor.

2D MoS₂ is being intensively investigated as a promising candidate to extend the downscaling of electronic devices. Here, the authors report a buffer-layer-control method for the growth of wafer-scale single-crystalline MoS₂ monolayers on industry-compatible sapphire substrates with competitive optical and electronic properties.

G protein-coupled receptors (GPCRs) are a critical target in modern drug development across a wide range of indications. Here the authors provide a comprehensive characterization of a typical GPCR, the angiotensin II (AngII) type 1 receptor (AT1R), and provide insight into its activation mechanism that suggest avenues for the design of allosteric GPCR modulators.

Although single atom catalysts (SACs) with high-loading metal-Nx have great potential in heterogeneous catalysis, their scalable synthesis remains challenging. Here, the authors develop a general cascade anchoring strategy for the mass production of a series of metal-Nx SACs with a metal loading up to 12.1 wt%.

The Brassica rapa Genome Sequencing Project Consortium reports the draft genome of the B. rapa accession Chiifu-401-42, an inbred Chinese cabbage line. The B. rapa genome should provide a useful reference genome for the Brassica species, which include many important oil and vegetable crops.

Brassica oleracea is plant species comprising economically important vegetable crops. Here, the authors report the draft genome sequence of B. oleracea and, through a comparative analysis with the closely related B. rapa, reveal insights into Brassicaevolution and divergence of interspecific genomes and intraspecific subgenomes.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

The authors examine the spin polaron pair dissociation at interfacial charge transfer states for various organic solar cells at working conditions through a joint of magneto-photocurrent experiments and coherent spin-mixing analyses. In this work, they unveil the relationship between photophysical quantities and photovoltaic performance.

A small-molecule manganese-based catalyst has been developed for the selective oxidation of strong methylene C–H bonds in the presence of more oxidatively labile aromatic functionality. This reaction enables the late-stage oxidative derivatization of medicinally relevant compound scaffolds and may also prove useful for diversifying aromatic drugs and natural products, as well as helping to quickly identify their metabolites.

Delineating the specific role of Polycomb Repressive Complex 2 (PRC2) in various cancer systems is desirable as inhibitors for EZH2 inhibitors are approved for some cancers. Here the authors show haplo- and full-insufficiency of EZH2 drive divergent phenotypes in lung cancer. 3D tumoroids recapitulate transcriptional profiles, including FOXP2 derepression, and drug responses of in vivo tumors.

A manganese catalyst is reported that aminates C–H bonds via a mechanism that lies between that of reactive noble metals (concerted) and chemoselective base metals (stepwise). Rather than exhibiting intermediate reactivity and selectivity, [Mn(^tBuPc)] is an outlier, and aminates all C(sp³)–H bonds, including 1°, while remaining tolerant of oxidizable π-functionality.

A dual-coupling-guided growth mechanism enables the realization of wafer-scale single-crystal WS₂ on vicinal a-plane sapphire.

Placing two Bernal-stacked graphene bilayers on top of each other with a small twist angle gives correlated states. As the band structure can be tuned by an electric field, this platform is a more varied setting to study correlated electrons.