Cross-coupling reactions between aryl halides and alcohols using copper are challenging due to the energetically demanding oxidative addition of copper into aryl halides. Now, this high-barrier step is bypassed using an energy transfer or direct excitation strategy for copper-mediated cross-coupling reactions. This process enables the use of aryl chlorides as electrophiles and alcohols, amines and fluoride as nucleophilic coupling partners.
- Li Zhang
- Eva M. Israel
- Tobias Ritter
