Nature Search

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models

DNA methylation and copy number variant analyses across a large number of genetic mouse models of pediatric brain tumors reveal subtype-specific molecular alterations shared with the corresponding human diseases.

Melanie Schoof
Tuyu Zheng
Marc Zuckermann
ResearchOpen Access11 Dec 2025
Nature Genetics

Volume: 58, P: 143-156
Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4

This study demonstrates a role of cholesterol metabolism-related gene, Lrp3, in cartilage degeneration and osteoarthritis pathogenesis. LRP3 positively regulates cartilage extracellular matrix metabolism by targeting syndecan-4 via Ras signalling, implicating the cholesterol-LRP3-SDC4 axis in osteoarthritic cartilage degeneration.

Chenxi Cao
Yuanyuan Shi
Yingfang Ao
ResearchOpen Access21 Nov 2022
Nature Communications

Volume: 13, P: 1-16
A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

Loss of cartilage tissue is a hallmark of osteoarthritis. Here the authors show that BNTA, a small molecule identified in a chemical screen, promotes ECM generation in human osteoarthritic chondrocytes and cartilage explants, and suppresses pathology in a rat model of osteoarthritis.

Yuanyuan Shi
Xiaoqing Hu
Yingfang Ao
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-14
Magnetic order close to superconductivity in the iron-based layered LaO_1-xF _x FeAs systems

Clarina de la Cruz
Q. Huang
Pengcheng Dai
Research28 May 2008
Nature

Volume: 453, P: 899-902
Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

Cryo-EM structures of HIV-1 capsid in tubular assemblies feature intrinsically curved and asymmetric hexamers and provide insight into cyclophilin A binding.

Tao Ni
Samuel Gerard
Peijun Zhang
Research03 Aug 2020
Nature Structural & Molecular Biology

Volume: 27, P: 855-862
The potential of using semitendinosus tendon as autograft in rabbit meniscus reconstruction

Chenxi Li
Xiaoqing Hu
Yingfang Ao
ResearchOpen Access01 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Hong Xue
Zhenhua Feng
Xuewu Sun
Amendments and CorrectionsOpen Access09 Jul 2024
Cell Death Discovery

Volume: 10, P: 1
Inhibition of transforming growth factor β-activated kinase 1 prevents inflammation-related cartilage degradation in osteoarthritis

Jin Cheng
Xiaoqing Hu
Yingfang Ao
ResearchOpen Access29 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
Performance of the multi-U-style structure based flow field for polymer electrolyte membrane fuel cell

Wenjie Qi
Xin Chen
Junjie Cheng
ResearchOpen Access07 Oct 2024
Scientific Reports

Volume: 14, P: 1-17
Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Hong Xue
Zhenhua Feng
Xuewu Sun
ResearchOpen Access15 Feb 2024
Cell Death Discovery

Volume: 10, P: 1-15
The Fd-GOGAT1 mutant gene lc7 confers resistance to Xanthomonas oryzae pv. Oryzae in rice

Honglin Chen
Chunrong Li
Wenxue Zhai
ResearchOpen Access23 May 2016
Scientific Reports

Volume: 6, P: 1-13

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Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models

Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4

A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

Magnetic order close to superconductivity in the iron-based layered LaO_1-xF _x FeAs systems

Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

The potential of using semitendinosus tendon as autograft in rabbit meniscus reconstruction

Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Inhibition of transforming growth factor β-activated kinase 1 prevents inflammation-related cartilage degradation in osteoarthritis

Performance of the multi-U-style structure based flow field for polymer electrolyte membrane fuel cell

Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

The Fd-GOGAT1 mutant gene lc7 confers resistance to Xanthomonas oryzae pv. Oryzae in rice

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