Nature Search

In vivo mitochondrial base editing restores genotype and visual function in a mouse model of LHON

Leber hereditary optic neuropathy (LHON) is caused by mtDNA mutations. Here, authors generated a mouse model with the common LHON mutation and showed that optimized TALE-like deaminases restored both phenotype and genotype via high-fidelity mitochondrial base editing.

Sanghun Kim
Jieun Kim
Hyunji Lee
ResearchOpen Access23 Nov 2025
Nature Communications

Volume: 16, P: 1-18
Efficacy of pregabalin for the treatment of chronic pruritus of unknown origin, assessed based on electric current perception threshold

JaeIn Lee
DongHyek Jang
JiYoung Ahn
ResearchOpen Access23 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
Developmental self-reactivity determines pathogenic Tc17 differentiation potential of naive CD8⁺ T cells in murine models of inflammation

The heterogeneity in naive CD8⁺ T cells is essential for diverse immune responses. Here the authors show that variations in developmental self-reactivity of CD8⁺ T cells influence their differentiation into T_c17 cells in inflammatory conditions.

Gil-Woo Lee
Young Ju Kim
Jae-Ho Cho
ResearchOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1-16
Effects of bioactive glass incorporation into glass ionomer cement on demineralized dentin

Hyun-Jung Kim
Han Eul Bae
Duck-Su Kim
ResearchOpen Access29 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
Direct observation of DNA target searching and cleavage by CRISPR-Cas12a

Cas12a is a RNA-guided DNA endonuclease whose detailed mechanisms of target searching and DNA cleavage remained unclear. Here authors use single-molecule fluorescence assays to show that Cas12a searches for their on-target site.

Yongmoon Jeon
You Hee Choi
Sangsu Bae
ResearchOpen Access17 Jul 2018
Nature Communications

Volume: 9, P: 1-11
A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus

Monoclonal antibodies with broadly neutralizing activity are being developed as potential treatment of influenza infections. Here, the authors describe a broadly neutralizing antibody with an unusual mode of binding to viral haemagglutinin, which has been isolated from patients convalescent from pandemic H1N1 influenza infection.

Ying Wu
MyungSam Cho
Ruben O. Donis
ResearchOpen Access21 Jul 2015
Nature Communications

Volume: 6, P: 1-11
Arsenite exposure suppresses adipogenesis, mitochondrial biogenesis and thermogenesis via autophagy inhibition in brown adipose tissue

Jiyoung Bae
Yura Jang
Seung-Hyun Ro
ResearchOpen Access08 Oct 2019
Scientific Reports

Volume: 9, P: 1-14
Discovery and preclinical efficacy of HSG4112, a synthetic structural analog of glabridin, for the treatment of obesity

Leo Sungwong Choi
In Geun Jo
Sang-Ku Yoo
ResearchOpen Access17 Sept 2020
International Journal of Obesity

Volume: 45, P: 130-142
Exploring potential multiple molecular biomarkers that predict treatment response in patients with lupus nephritis

Dae Jin Park
Young Bin Joo
Sang-Cheol Bae
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-11
LRRC10 regulates mammalian cardiomyocyte cell cycle during heart regeneration

Rebecca J. Salamon
Megan C. McKeon
Ahmed I. Mahmoud
ResearchOpen Access28 Jul 2023
npj Regenerative Medicine

Volume: 8, P: 1-8

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