Nature Search

Diversity and structure of genes of the α family of mouse T-cell antigen receptor

Bernhard Arden
Joan L. Klotz
Leroy E. Hood
Research29 Aug 1985
Nature

Volume: 316, P: 783-787
Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

Mitchell Kronenberg
Joan Goverman
Leroy Hood
Research21 Feb 1985
Nature

Volume: 313, P: 647-653
Predominant use of a V_α gene segment in mouse T-cell receptors for cytochrome c

Astar Winoto
James L. Urban
Daniel Hansburg
Research18 Dec 1986
Nature

Volume: 324, P: 679-682
MHC class I–restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8⁺ T cells

Autoreactive CD8⁺ T cells are prevalent in multiple sclerosis. Goverman and colleagues identify tumor necrosis factor–inducible nitric oxide synthase (TNF-iNOS)-producing dendritic cells that cross-present myelin antigen to activate naive CD8⁺ T cells in the central nervous system.

Qingyong Ji
Luca Castelli
Joan M Goverman
Research06 Jan 2013
Nature Immunology

Volume: 14, P: 254-261
Viral infection triggers central nervous system autoimmunity via activation of CD8⁺ T cells expressing dual TCRs

Whether environmental antigens can elicit autoimmunity remains unclear. Goverman and colleagues show that viral infection breaks self-tolerance via activation of CD8⁺ T cells expressing dual T cell antigen receptors, without bystander activation or molecular mimicry.

Qingyong Ji
Antoine Perchellet
Joan M Goverman
Research06 Jun 2010
Nature Immunology

Volume: 11, P: 628-634
Autoimmune T cell responses in the central nervous system

Our understanding of the role of T cells in the induction of autoimmune disease in the central nervous system has progressed rapidly in recent years. Here, Joan Goverman provides us with a comprehensive overview of this field and discusses the controversies that remain.

Joan Goverman
Reviews01 Jun 2009
Nature Reviews Immunology

Volume: 9, P: 393-407
Passive induction of experimental allergic encephalomyelitis

Ingunn M Stromnes
Joan M Goverman
Protocols22 Nov 2006
Nature Protocols

Volume: 1, P: 1952-1960
Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in cell culture and in an animal model of MS.

Leslie Kirby
Jing Jin
Peter A. Calabresi
ResearchOpen Access29 Aug 2019
Nature Communications

Volume: 10, P: 1-20
Differential regulation of central nervous system autoimmunity by T_H1 and T_H17 cells

Ingunn M Stromnes
Lauren M Cerretti
Joan M Goverman
Research17 Feb 2008
Nature Medicine

Volume: 14, P: 337-342
Speaking out about gender imbalance in invited speakers improves diversity

Omissions of qualified women scientists from major meeting programs continue to occur despite a surge in articles indicating persistent gender-discriminatory practices in hiring and promotion, and calls for gender balance in conference organizing committees.

Robyn S Klein
Rhonda Voskuhl
Anne H Cross
Comments & Opinion18 Apr 2017
Nature Immunology

Volume: 18, P: 475-478
CD8⁺ T cells maintain tolerance to myelin basic protein by 'epitope theft'

Antoine Perchellet
Ingunn Stromnes
Joan Goverman
Research16 May 2004
Nature Immunology

Volume: 5, P: 606-614
Osteopontin-induced survival of T cells

Relapses and exacerbation of clinical symptoms are hallmarks of debilitating autoimmune diseases like multiple sclerosis. Osteopontin-induced survival of autoreactive T cells may be one mechanism underlying the clinical progression of autoimmune disease.

Ingunn M Stromnes
Joan M Goverman
News & Views01 Jan 2007
Nature Immunology

Volume: 8, P: 19-20
Cytokine networks in neuroinflammation

This Review discusses the contribution of different cytokine networks to inflammation in the central nervous system (CNS). In neuroinflammatory diseases such as multiple sclerosis, CNS-invading leukocytes produce many of the cytokines that are associated with disease. By contrast, in Alzheimer disease and other neurodegenerative diseases, tissue-resident cells are the main source of pathological cytokines.

Burkhard Becher
Sabine Spath
Joan Goverman
Reviews05 Dec 2016
Nature Reviews Immunology

Volume: 17, P: 49-59
Active induction of experimental allergic encephalomyelitis

Ingunn M Stromnes
Joan M Goverman
Protocols16 Nov 2006
Nature Protocols

Volume: 1, P: 1810-1819

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