Generalised pustular psoriasis (GPP) is a severe type of psoriasis characterized by epidermal neutrophil infiltration and potentially life-threatening flares. Here the authors use single cell and spatial transcriptomic analysis of skin samples implicating contact between IL36G+ keratinocytes and neutrophils as well as ligand-receptor interactions of fibroblasts with T cells, neutrophils or macrophages.
- Rundong Jiang
- Joseph Kirma
- Johann E. Gudjonsson
