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Showing 1–50 of 62 results

Advanced filters: Author: Joao Matos Clear advanced filters

Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response

The immune response to tumour development is frequently targeted with therapeutics but remains largely unexplored in diagnostics. Here this groups designs an immunodiagnostic platform targeting amino acid residue biomarkers associated with tumour development and distinct from autoimmune and infectious diseases.

Cong Tang
Patrícia Corredeira
Gonçalo J. L. Bernardes
ResearchOpen Access14 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Holliday junction–ZMM protein feedback enables meiotic crossover assurance

Holliday junctions maintain chromosome synapsis to enable crossover assurance in budding yeast.

Adrian Henggeler
Lucija Orlić
Joao Matos
ResearchOpen Access24 Sept 2025
Nature

Volume: 647, P: 766-775
Skin tone and clinical dataset from a prospective trial on acute care patients

Sicheng Hao
Joao Matos
An-Kwok Ian Wong
ResearchOpen Access28 Jan 2026
Scientific Data

P: 1-8
Phosphorylation of peptides by a kinase domain in cyanobactin pathways

Phosphorylation is a key protein modification but rare in natural product biosynthesis. Here, authors discover cyanobacterial pathways that encode a kinase domain, leading to the production of phosphorylated peptides and expanding the diversity and engineering potential of cyanobactins.

Raquel Castelo-Branco
Xiaodan Ouyang
Pedro N. Leão
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

Interleukin-7 receptor alpha (IL7Ra) is important for lymphoid cell development but its role in leukaemogenesis is not clear. Here, the authors generate a knock-in murine model to show that activating mutations in IL7Ra can initiate precursor B-cell acute lymphoblastic leukaemia.

Afonso R. M. Almeida
João L. Neto
João T. Barata
ResearchOpen Access14 Dec 2021
Nature Communications

Volume: 12, P: 1-16
Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges

Here, in a longitudinal cohort of 1245 hospital care workers and 146 nursing home residents, the authors find that a large inter-individual variation in anti-spike antibody levels after one dose of BNT162b2mRNA vaccine is partially explained by age, sex, previous exposure, and treatments, while the 2nd dose is required to reach sero-conversion at the population level.

João Faro-Viana
Marie-Louise Bergman
Jocelyne Demengeot
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-8
Sport mental health continuum in young Brazilian athletes: adaptation and psychometric properties

Willen Remon Tozetto
Fabrício João Milan
Michel Milistetd
ResearchOpen Access05 Oct 2024
Scientific Reports

Volume: 14, P: 1-11
Publisher Correction: Regulation of the MLH1–MLH3 endonuclease in meiosis

Elda Cannavo
Aurore Sanchez
Petr Cejka
Amendments and Corrections19 Jan 2021
Nature

Volume: 590, P: E29
SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Borges et al. study the dynamics of SARS-CoV-2 in Portugal during 2020. The authors use phylodynamic modelling to infer patterns of SARS-CoV-2 introduction into Portugal and its subsequent spread, providing a comprehensive genomic epidemiology study of the early SARS-CoV-2 epidemic in Portugal.

Vítor Borges
Joana Isidro
João Paulo Gomes
ResearchOpen Access28 Jan 2022
Communications Medicine

Volume: 2, P: 1-11
Potential of biochar to restoration of microbial biomass and enzymatic activity in a highly degraded semiarid soil

Francisco L. A. Barbosa
João M. R. Santos
Arthur Prudêncio de Araujo Pereira
ResearchOpen Access30 Oct 2024
Scientific Reports

Volume: 14, P: 1-13
Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

Combination of dendritic-cell-targeted nanovaccines with a myeloid-derived suppressor cell inhibitor and immune checkpoint modulators expands the host antitumour immune cells, restricts tumour growth and prolongs survival in orthotopic melanoma models.

João Conniot
Anna Scomparin
Helena F. Florindo
Research05 Aug 2019
Nature Nanotechnology

Volume: 14, P: 891-901
Inhibition of the norA gene expression and the NorA efflux pump by the tannic acid

Saulo Relison Tintino
Polrat Wilairatana
Tereza Cristina Leal Balbino
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
Genetic and environmental factors regulating blood pressure in childhood: prospective study from 0 to 3 years

A Guerra
C Monteiro
M Bicho
Research01 Apr 1997
Journal of Human Hypertension

Volume: 11, P: 233-238
O armário: Fruiting phenology data for 4,462 plant taxa in Portugal (1926–2013)

Ruben Heleno
José M. Costa
Sérgio Timóteo
ResearchOpen Access22 Jun 2024
Scientific Data

Volume: 11, P: 1-7
Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma

João L. Pereira
Liliana Arede
Nuno R. dos Santos
Research25 Oct 2024
Leukemia

Volume: 39, P: 178-188
Author Correction: Ensemble learning for fetal ultrasound and maternal–fetal data to predict mode of delivery after labor induction

Iolanda Ferreira
Joana Simões
Ana Luísa Areia
Amendments and CorrectionsOpen Access06 Aug 2024
Scientific Reports

Volume: 14, P: 1
Regulation of the MLH1–MLH3 endonuclease in meiosis

Reconstitution of the activation of the MLH1–MLH3 endonuclease shows how crossovers are formed during meiosis.

Elda Cannavo
Aurore Sanchez
Petr Cejka
Research19 Aug 2020
Nature

Volume: 586, P: 618-622
The ophthalmologist’s guide to clinical practice guidelines: the GRADE evidence-to-decision frameworks and GRADE-Adolopment

João Pedro Lima
Dena Zeraatkar
SriniVas R. Sadda
Editorial09 Dec 2025
Eye

Volume: 40, P: 153-156
BrtB is an O-alkylating enzyme that generates fatty acid-bartoloside esters

O-alkylation of carboxylates by alkyl halides has only been observed transiently in enzymatic processes. Here, the authors show a carboxylate alkylating enzyme, BrtB, that catalyzes C-O bond formation between free fatty acids and secondary alkyl chlorides.

João P. A. Reis
Sandra A. C. Figueiredo
Pedro N. Leão
ResearchOpen Access19 Mar 2020
Nature Communications

Volume: 11, P: 1-9
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

Macrophages undergo a Warburg-like switch from oxidative phosphorylation to glycolysis in response to inflammatory stimulus. Here the authors show that fungal melanin can trigger this switch in human macrophages by sequestering calcium in the phagosome and enabling protection against Aspergillus fumigatus infection.

Samuel M. Gonçalves
Cláudio Duarte-Oliveira
Agostinho Carvalho
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-15
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE

Diogo Pestana
Diana Teixeira
Conceição Calhau
ResearchOpen Access01 Jun 2017
Scientific Reports

Volume: 7, P: 1-16
Unaccounted for nonforest vegetation loss in the Brazilian Amazon

Most non-forest vegetation losses in the Brazilian Amazon happened during the last two decades in the states of Mato Grosso, Roraima and Amapá, according to a monitoring system which accounts for losses in these often neglected non-forest biomes

Cassiano Gustavo Messias
Cláudio A. de Almeida
Marcos Adami
ResearchOpen Access21 Aug 2024
Communications Earth & Environment

Volume: 5, P: 1-9
A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma

Song Fan
Qiong‐lan Tang
Lei Wang
Reviews01 Oct 2011
International Journal of Oral Science

Volume: 3, P: 180-191
Sensor based sleep patterns and reported sleep quality in breast cancer patients undergoing neoadjuvant chemotherapy

Carla Malveiro
Sofia Boavida
Pedro F. Saint-Maurice
ResearchOpen Access11 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Advancing molecular modeling and reverse vaccinology in broad-spectrum yellow fever virus vaccine development

Ohana Leticia Tavares da Silva
Maria Karolaynne da Silva
Jonas Ivan Nobre Oliveira
ResearchOpen Access12 May 2024
Scientific Reports

Volume: 14, P: 1-24
Ensemble learning for fetal ultrasound and maternal–fetal data to predict mode of delivery after labor induction

Iolanda Ferreira
Joana Simões
Ana Luísa Areia
ResearchOpen Access03 Jul 2024
Scientific Reports

Volume: 14, P: 1-13
Seasonal singing of a songbird living near the equator correlates with minimal changes in day length

Rene Quispe
João Marcelo Brazão Protazio
Manfred Gahr
ResearchOpen Access22 Aug 2017
Scientific Reports

Volume: 7, P: 1-6
Molecular diagnosis of Huntington disease in Portugal: implications for genetic counselling and clinical practice

Maria do Carmo Costa
Paula Magalhães
Jorge Sequeiros
Research22 Oct 2003
European Journal of Human Genetics

Volume: 11, P: 872-878
Assessment of the myocardial effects of Bradykinin inhibitors by cardiac magnetic resonance (CMR) in discharged COVID-19 patients

Adriana Aparecida Bau
Roberto Schreiber
Otávio Rizzi Coelho-Filho
ResearchOpen Access11 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Biodiversity hotspots and threatened species under human influence in the Amazon continental shelf

Alex Garcia Cavalleiro de Macedo Klautau
Ana Patricia Barros Cordeiro
Bianca Bentes
ResearchOpen Access22 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Treatment of a metabolic liver disease by in vivo genome base editing in adult mice

AAV-mediated base editing corrects an autosomal recessive mutation in the Pah^enu2 gene and ameliorates molecular deficits in a mouse model of metabolic liver disease.

Lukas Villiger
Hiu Man Grisch-Chan
Gerald Schwank
Research08 Oct 2018
Nature Medicine

Volume: 24, P: 1519-1525
Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development

The genetic and microenvironmental heterogeneity of colorectal cancer is analyzed using a prospective biobank of primary and metastatic tumor tissues to highlight features of intra-tumoral heterogeneity that favor tumor progression and metastasis.

Daniel Sobral
Marta Martins
Luis Costa
ResearchOpen Access09 Sept 2022
Communications Biology

Volume: 5, P: 1-14
Correction to: Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases

Birte Zurek
Kornelia Ellwanger
Andreas Rump
Amendments and Corrections13 Aug 2021
European Journal of Human Genetics

Volume: 29, P: 1459-1461
Correction: Solving unsolved rare neurological diseases—a Solve-RD viewpoint

Rebecca Schüle
Dagmar Timmann
Andreas Rump
Amendments and Corrections25 Aug 2021
European Journal of Human Genetics

Volume: 29, P: 1462-1465
Correction to: Solving patients with rare diseases through programmatic reanalysis of genome-phenome data

Leslie Matalonga
Carles Hernández-Ferrer
Andreas Rump
Amendments and Corrections16 Aug 2021
European Journal of Human Genetics

Volume: 29, P: 1466-1469
Effective reduction of unnecessary biopsies through a deep-learning-assisted aggressive prostate cancer detector

Nuno M. Rodrigues
José Guilherme de Almeida
Nickolas Papanikolaou
ResearchOpen Access30 Apr 2025
Scientific Reports

Volume: 15, P: 1-15
Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber

A complex Nuclear Receptor Element (cNRE) of 32 base pairs that emerged from a viral infection drives the quail Slow Myosin Heavy Chain III (SMyHC III) promoter preferential expression to the atria.

Luana Nunes Santos
Ângela Maria Sousa Costa
José Xavier-Neto
ResearchOpen Access04 Apr 2024
Communications Biology

Volume: 7, P: 1-15
Schistosoma mansoni vaccine candidates identified by unbiased phage display screening in self-cured rhesus macaques

Daisy Woellner-Santos
Ana C. Tahira
Sergio Verjovski-Almeida
ResearchOpen Access04 Jan 2024
npj Vaccines

Volume: 9, P: 1-19
Value of handcrafted and deep radiomic features towards training robust machine learning classifiers for prediction of prostate cancer disease aggressiveness

Ana Rodrigues
Nuno Rodrigues
Nickolas Papanikolaou
ResearchOpen Access17 Apr 2023
Scientific Reports

Volume: 13, P: 1-10
Correction: Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Radoslaw Szmyd
Joanna Niska-Blakie
Philipp Kaldis
Amendments and CorrectionsOpen Access21 Nov 2019
Oncogene

Volume: 39, P: 2030
Leaf transcriptome profiling of contrasting sugarcane genotypes for drought tolerance under field conditions

Danyel Fernandes Contiliani
João Felipe Carlos de Oliveira Nebó
Silvana Creste
ResearchOpen Access01 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy

Adriana Marcelo
Inês T. Afonso
Clévio Nóbrega
ResearchOpen Access29 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-13
Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions

Vasco Silva-Neves
Vitor Hugo
Miguel Pais-Vieira
ResearchOpen Access17 Jun 2021
Scientific Reports

Volume: 11, P: 1-10
Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Radoslaw Szmyd
Joanna Niska-Blakie
Philipp Kaldis
ResearchOpen Access06 Sept 2018
Oncogene

Volume: 38, P: 998-1018
Analysis of Arabidopsis thaliana Redox Gene Network Indicates Evolutionary Expansion of Class III Peroxidase in Plants

Raffael Azevedo de Carvalho Oliveira
Abraão Silveira de Andrade
Rodrigo Juliani Siqueira Dalmolin
ResearchOpen Access31 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Comparison of the ABC and ACMG systems for variant classification

Gunnar Houge
Eirik Bratland
Andreas Laner
ResearchOpen Access22 May 2024
European Journal of Human Genetics

Volume: 32, P: 858-863
Novel 2-pheynlbenzofuran derivatives as selective butyrylcholinesterase inhibitors for Alzheimer’s disease

Amit Kumar
Francesca Pintus
Antonella Fais
ResearchOpen Access13 Mar 2018
Scientific Reports

Volume: 8, P: 1-12
Beta-hemolytic Streptococcus dysgalactiae strains isolated from horses are a genetically distinct population within the Streptococcus dysgalactiae taxon

Marcos D. Pinho
Erdal Erol
Mario Ramirez
ResearchOpen Access17 Aug 2016
Scientific Reports

Volume: 6, P: 1-9
Effect of Laminaria digitata dietary inclusion and CAZyme supplementation on blood cells, serum metabolites and hepatic lipids and minerals of weaned piglets

David M. Ribeiro
Rui M. A. Pinto
José A. M. Prates
ResearchOpen Access22 Apr 2023
Scientific Reports

Volume: 13, P: 1-11
Bioprospecting for industrially relevant exopolysaccharide-producing cyanobacteria under Portuguese simulated climate

José Diogo Cruz
Cédric Delattre
Vitor Vasconcelos
ResearchOpen Access21 Aug 2023
Scientific Reports

Volume: 13, P: 1-16

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