Nature Search

Prevention of type 2 diabetes through prediabetes remission without weight loss

A post hoc analysis of a multicentre, randomised trial showed that prediabetes remission is possible without total weight loss—providing weight is distributed to subcutaneous deposits as opposed to visceral ones.

Arvid Sandforth
Elsa Vazquez Arreola
Reiner Jumpertz von Schwartzenberg
ResearchOpen Access29 Sept 2025
Nature Medicine

Volume: 31, P: 3330-3340
Cortical dynamics during cell motility are regulated by CRL3^KLHL21 E3 ubiquitin ligase

Although focal adhesions (FAs) and microtubules (MTs) are known to associate, the underlying regulation of this dynamic interaction is not understood. Here the authors discover that the CRL3^KLHL21E3 ubiquitin ligase localises to FAs and ubiquitinates the MT plus-tip binding protein EB1, thereby promoting MT and FA dynamics and cell migration.

Thibault Courtheoux
Radoslav I. Enchev
Matthias Peter
ResearchOpen Access19 Sept 2016
Nature Communications

Volume: 7, P: 1-13
A pan-cancer analysis reveals nonstop extension mutations causing SMAD4 tumour suppressor degradation

Dhamija et al. profile 3,412 nonstop mutations from 62 tumour entities and as proof of concept demonstrate that six such mutations cause degradation and loss of the tumour suppressor SMAD4.

Sonam Dhamija
Chul Min Yang
Sven Diederichs
Research27 Jul 2020
Nature Cell Biology

Volume: 22, P: 999-1010
Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex

The axon initial segment (AIS) is critical for action potential initiation and implicated in the regulation of neuronal excitability. The authors describe bidirectional AIS plasticity in a behaviourally relevant context, revealing that the AIS acts in vivo as a homeostatic regulatory domain.

Nora Jamann
Dominik Dannehl
Maren Engelhardt
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-14
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity

Marcus Maurer
Jochen Wedemeyer
Stephen J. Galli
Research14 Nov 2004
Nature

Volume: 432, P: 512-516
Structural variation in the pangenome of wild and domesticated barley

A pangenome analysis of 76 wild and domesticated barley accessions in combination with short-read sequence data of 1,315 barley genotypes indicates that allelic diversity at structurally complex loci may have helped crop plants to adapt to agricultural ecosystems.

Murukarthick Jayakodi
Qiongxian Lu
Nils Stein
ResearchOpen Access13 Nov 2024
Nature

Volume: 636, P: 654-662
The International Primary Care Respiratory Group (IPCRG) Research Needs Statement 2010

Hilary Pinnock
Mike Thomas
Sian Williams
Research31 May 2010
Primary Care Respiratory Journal

Volume: 19, P: S1-S20
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

KMT9, a new histone lysine methyltransferase targeting H4K12, is enriched at promoters of genes encoding molecules involved in the cell cycle and controls the growth of androgen receptor–dependent and castration- and enzalutamide-resistant prostate cancer cells and xenograft tumors.

Eric Metzger
Sheng Wang
Roland Schüle
Research06 May 2019
Nature Structural & Molecular Biology

Volume: 26, P: 361-371
Sub-cycle time resolution of multi-photon momentum transfer in strong-field ionization

Understanding momentum transfer in light–matter interaction is intriguing. Here the authors study momentum transfer from photons to electrons and observe a time delay in the linear momentum transfer during strong-field ionization of xenon atoms using time-resolved measurements with velocity map imaging.

Benjamin Willenberg
Jochen Maurer
Ursula Keller
ResearchOpen Access05 Dec 2019
Nature Communications

Volume: 10, P: 1-8
Precision phenotyping of biomass accumulation in triticale reveals temporal genetic patterns of regulation

Lucas Busemeyer
Arno Ruckelshausen
Tobias Würschum
ResearchOpen Access14 Aug 2013
Scientific Reports

Volume: 3, P: 1-6
EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer

Michael Rose
Angela Maurer
Nadine T. Gaisa
ResearchOpen Access25 Sept 2020
Oncogene

Volume: 39, P: 6856-6870
Correction: EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer

Michael Rose
Angela Maurer
Nadine T. Gaisa
Amendments and Corrections01 Dec 2020
Oncogene

Volume: 40, P: 1390
Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype

Maximilian Seidl
Moritz Bader
Peter Bronsert
ResearchOpen Access28 Mar 2018
Scientific Reports

Volume: 8, P: 1-12
Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant

Michael Fichtner
Emir Bozkurt
Jochen H. M. Prehn
ResearchOpen Access30 Nov 2020
Cell Death & Disease

Volume: 11, P: 1-16
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
CD30-mediated cell cycle arrest associated with induced expression of p21^CIP1/WAF1 in the anaplastic large cell lymphoma cell line Karpas 299

Gabriele Hübinger
Elke Müller
Lothar Bergmann
Research25 Mar 2001
Oncogene

Volume: 20, P: 590-598

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