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Shared genetic architecture between eating disorders, mental health conditions, and cardiometabolic diseases: a comprehensive population-wide study across two countries

Here, the authors’ findings highlight genetic overlap between eating disorders, mental disorders, and cardiometabolic diseases, supporting the need for integrated treatment strategies across physical and mental health care.

Joeri Meijsen
Kejia Hu
Nadia Micali
ResearchOpen Access04 Jul 2025
Nature Communications

Volume: 16, P: 1-10
Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians

Mental disorders are often linked with cardiometabolic disorders, but the mechanism remains unclear. Here, the authors use comprehensive health data from Denmark and to shed light on the genetic and environmental factors influencing the co-occurrence of six mental disorders and 15 cardiometabolic disorders.

Joeri Meijsen
Kejia Hu
Alfonso Buil
ResearchOpen Access13 Jun 2024
Nature Communications

Volume: 15, P: 1-10
Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression

Genome-wide association analyses leveraging Nordic biobanks with longitudinal health registries identify differences in the genetic architectures of early-onset and late-onset major depressive disorder and in their genetic correlations with related traits.

John R. Shorter
Joëlle A. Pasman
Yi Lu
ResearchOpen Access13 Nov 2025
Nature Genetics

Volume: 57, P: 2972-2979
Trans-ancestry GWAS of hot flashes reveals potent treatment target and overlap with psychiatric disorders

Werwath, Lawn et al. conduct a large trans-ancestry genome-wide association study (GWAS) of hot flashes among post-menopausal women age 35-88. The findings reveal a locus on chromosome 4 and multiple genes linked to hot flashes, suggesting potential mechanisms and treatment targets.

Kathryn E. Werwath
Rebecca B. Lawn
Laramie E. Duncan
ResearchOpen Access06 Jan 2026
Communications Medicine

Volume: 6, P: 1-11
Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Bergstedt et al. show that the effects of genetic liability to major depressive disorder can cause an increase in cardiovascular risk and that metabolic, psychological and lifestyle factors are partly responsible for this association.

Jacob Bergstedt
Joëlle A. Pasman
Fang Fang
ResearchOpen Access17 Jun 2024
Nature Cardiovascular Research

Volume: 3, P: 754-769
Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up

Marit Haram
Andreas Jangmo
Martin Tesli
ResearchOpen Access17 Sept 2025
Molecular Psychiatry

P: 1-8
Associations between testosterone and future PTSD symptoms among middle age and older UK residents

Hanyang Shen
Ciera Stafford
Laramie E. Duncan
ResearchOpen Access06 Aug 2025
Translational Psychiatry

Volume: 15, P: 1-9
Phenotypic and genetic analysis of cognitive performance in Major Depressive Disorder in the Generation Scotland: Scottish Family Health Study

Joeri J. Meijsen
Archie Campbell
Kristin K. Nicodemus
ResearchOpen Access13 Mar 2018
Translational Psychiatry

Volume: 8, P: 1-9
Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology

Simone Montalbano
Morten Dybdahl Krebs
Andrés Ingason
ResearchOpen Access19 Dec 2024
npj Genomic Medicine

Volume: 9, P: 1-10

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