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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The Airy-Talbot effect is experimentally demonstrated for spoof surface acoustic waves in a structured metasurface. Owing to its self-imaging and self-healing properties, the authors achieve robust multipath transmission of nonperiodic signals.

Static cloaking and camouflage remain a central challenge in mechanics. Yang et al. introduce an irregular growth strategy with limited building blocks of varying stiffness, enabling complex void structures for effective cloaking and mutual camouflage under diverse loading.

Fullerenes possess unique electronic property influenced by their real space topology and gauge field. Here, the authors construct an acoustic C₅₄₀ fullerene metamaterial, allowing observation of 3D topological pentagon states using sound waves, and offering new insights into classical wave manipulation.

Single-wall carbon nanotubes are made of carbon with diameters less than 100 nanometers. Here, the authors engineer an analogue tube with a diameter 1,000,000 times larger with the aim to explore topological properties including unusual acoustic edge states.

Typically, sending sound from transmitter to receiver requires pre-amplification and disturbs the surrounding sound environment. Here, the authors present a metamaterial designed to enable transmission of weak sound that can be recovered even in the presence of strong noise

Nonreciprocal transmission of waves is crucial for transport and redistribution of energy, yet the architecture to break time-reversal symmetry is hard to realise. Here, the authors proposed elastic-wave circulator that could achieve this without breaking reciprocity, enabling mode transition and wave trapping concurrently.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

The interplay between competing orders in high-temperature superconductors can be tuned by the application of magnetic fields. Here, Chang et al. report high field induced three-dimensional charge density wave in underdoped YBa₂Cu₃O_6.67, which suggests Fermi surface reconstruction due to competing orders.

The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic conditions.

Active metamaterials can host non-Hermitian interactions that defy the conservation laws of linear elasticity, leading to unusual phenomena such as one-way energy transmission and odd-elastic moduli. Here, robust unidirectional Rayleigh surface waves are found in active media comprising both gyroscopic and odd-elastic effects.

An acoustic topological gallery insulator constructed from sonic crystals made of thermoplastic rods decorated with carbon nanotube films enables the out-coupling of amplified and focused sound at audible frequencies.

Denoising low-counting statistics data in the presence of multiple, unknown noise profiles is a challenging task in scientific applications where high accuracy is required. Oppliger and colleagues train a deep convolutional neural network on pairs of experimental low- and high-noise X-ray diffraction data and demonstrate better performance on experimental noise filtering compared with the case of training on artificial data pairs.

Meta-analyses in up to 1.3 million individuals identify 87 rare-variant associations with blood pressure traits. On average, rare variants exhibit effects ~8 times larger than the mean effects of common variants and implicate candidate causal genes at associated regions.

An αHER2 antibody–neuraminidase conjugate, which selectively targets the removal of sialic acids from glycans on breast cancer cells, bypasses a glycoimmune checkpoint and enhances tumor cell killing by the host immune system.

Chiral communication can propagate in secondary structures within the effective intermolecular force (IMF) range but it is not known whether long-range chiral communication exists between tertiary peptide structures. Here, the authors use single-molecule force spectroscopy to investigate chiral interaction between DNA duplexes/triplexes and peptide coiled-coils and demonstrate chiral communication beyond the IMF distance.

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

Localized zero-energy fermionic states can bind to topological defects such as two-dimensional vortices, which can be realized in the bulk of artificial acoustic and optical lattices.

Enzyme reactions at interfaces are common in both Nature and industrial applications but no general kinetic framework exists for interfacial enzymes. Here, the authors kinetically characterize 83 cellulases and identify a scaling relationship between ligand binding strength and maximal turnover, a so-called linear free energy relationship, which may help rationalize cellulolytic mechanisms and guide the selection of technical enzymes.

Aarno Palotie and colleagues present results of a large genome-wide association study of migraine. They identified significant associations at 38 distinct loci and found enrichment for genes expressed in vascular and smooth muscle tissues.

Using highly coherent interfaces of alternating oxide layers a bismuth-oxide-based oxygen ion conductor exhibits unprecedented high chemical stability in reducing conditions and during redox cycles at high temperature.

Peptide and oligonucleotide systems are known to self-assemble both in nature and artificial systems. Here, the authors combine both forms of self-assembly through the synthesis of peptideoligonucleotide conjugates and show formation of a three-helix structure that dimerises at higher concentrations.

Controlling elastic waves in medium is essential to many applications in mechanical to earthquake engineering. Ma et al. demonstrate selective suppression of different vibrational modes in a three-dimensional rod-shape structure, which shows fluid-like elasticity with only longitudinal waves propagating.

An international team of researchers finds high potential for improving climate projections by a more comprehensive treatment of largely ignored Arctic vegetation types, underscoring the importance of Arctic energy exchange measuring stations.

A system consisting of alternating thin films of two dielectrics is used to produce greatly enhanced electrostriction derived from coherent strain imparted by interfacial lattice discontinuity.

Topological boundary modes in mechanical systems have recently attracted great attention due to their unique protection features. Here, tunable corner localization of mechanical waves is numerically and experimentally demonstrated in a continuous elastic plate with hexagonally arranged bolts.

Topological metamaterials are becoming increasingly interesting for their wave-confining capabilities, providing topologically robust guiding of light, sound and vibrations. Here, topological edge and disclination states in valley Hall sonic lattices are investigated via a non-commercial analytical approach combining the null-field method with multiple scattering techniques.

Observations from the JWST of the second brightest GRB ever detected, GRB 230307A, indicate that it belongs to the class of long-duration GRBs resulting from compact object mergers, with the decay of lanthanides powering the longlasting optical and infrared emission.

Higher-order topological insulators are a class of systems where the relationship between the bulk and surface properties differ from that of conventional topological insulators. Here, the authors seek to demonstrate that these systems may be realized using acoustic systems.

Magnetic excitations in infinite-layer cuprates have been intensively studied. Here the authors use resonant inelastic x-ray scattering and theoretical calculations to study magnons in thin films of SrCuO₂, finding distinct magnon dispersion attributed to renormalization due to quantum fluctuations.

An individual star at z = 1.49 is gravitationally lensed and highly magnified by a foreground galaxy cluster. Fluctuations in the star’s emission provide insight on the mass function of intracluster stars, compact objects and the presence of dark-matter subhaloes.

Individual SNPs have small effects on anthropometric traits, yet the impact of CNVs has remained largely unknown. Here, Kutalik and co-workers perform a large-scale genome-wide meta-analysis of structural variation and find rare CNVs associated with height, weight and BMI with large effect sizes.

Analysing a database of >1,800 field studies in the terrestrial Arctic, the authors identify large spatial biases in sampling, with nearly one-third of all citations derived from sites located within 50 km of two research stations.

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

The intriguing physics of correlated flat bands in moiré superlattices can be mimicked, in classical physics, by twisted acoustic plates with periodic holes. Here, the authors derive a combined analytical and numerical approach that provides computational advantage in band engineering of holey bilayer plates.

Transverse stripe order fluctuations may promote superconductivity, but experimental verifications remain difficult. Here, the authors report that a mild uniaxial pressure changes the ordering pattern and pins the stripe order to the crystal axis in La_1.88Sr_0.12CuO₄.

NMR and ultrasound measurements show that the spin-glass phase exists in a cuprate all the way up to the doping that marks the end of the pseudogap phase. This highlights the possible connection between the pseudogap and Mott physics.

The optimal condition for superconductivity is a long-sought issue but remains challenging. Here, Ivashko et al. demonstrate that the compressive strain to La₂CuO₄ films enhances the Coulomb and magnetic-exchange interactions relevant for superconductivity, providing a strategy to optimise the parent Mott state for superconductivity.

Magnetic field induced competing phases in high-temperature superconductors provide a testbed for various theoretical scenarios. Here, Choi et al. report evidence of inhomogeneous superconducting state due to the different competition strength between two charge density wave orders in YBa₂Cu₃O_6.67.

White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

The association between blood pressure (BP) and migraine is poorly understood. Here, the authors explore this relationship using summary-level GWAS data for BP and migraine. Cross-trait meta-analysis reveals shared loci between BP and migraine, while Mendelian randomization suggests that diastolic BP specifically plays a key role in migraine susceptibility.

X-ray diffraction experiments reveal that spatial charge ordering occurs in the pseudogap state of YBa₂Cu₃O_6.67. Moreover, this charge ordered state competes with high-temperature superconductivity, and their relative strengths can be tuned using a magnetic field.