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Showing 1–2 of 2 results
Advanced filters: Author: Johannes Mehringer Clear advanced filters

  • Chromosome ends must be protected from fusion by NHEJ despite Ku binding to telomeres. Here, the authors show that at telomeres yeast Rap1 inhibits Ku’s translocation on DNA, preventing NHEJ and protecting telomeres without displacing Ku.

    • Stefano Mattarocci
    • Sonia Baconnais
    • Stéphane Marcand
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Itaconate is shown to non-covalently inhibit the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby modulating the production of mitochondrial peroxide and enhancing the type I interferon production.

    • Tomas Paulenda
    • Barbora Echalar
    • Maxim N. Artyomov
    Research
    Nature Metabolism
    Volume: 7, P: 1183-1203