Nature Search

The growth of light seed black holes in the early Universe

Cosmological simulations show that tiny black holes that formed from the first stars can grow far faster than expected to become the seeds of the supermassive black holes now observed by JWST at cosmic dawn.

Daxal H. Mehta
John A. Regan
Lewis Prole
Research21 Jan 2026
Nature Astronomy

P: 1-10
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

P: 1-12
Frequency Curves of Genera and Species

G. UDNY YULE
Research05 Jul 1924
Nature

Volume: 114, P: 10
Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents

John P. Murnane
John E. Byfield
Paula Calabro-Jones
Research29 May 1980
Nature

Volume: 285, P: 326-329
Pieces of science

John Maddox
Books & Arts10 May 1984
Nature

Volume: 309, P: 187
Rapid formation of massive black holes in close proximity to embryonic protogalaxies

The key ingredients for a massive cloud of gas to collapse and directly form a black hole without fragmenting and forming stars are a strong ionizing background emission and a closely timed burst of star formation in its vicinity.

John A. Regan
Eli Visbal
Greg L. Bryan
Research13 Mar 2017
Nature Astronomy

Volume: 1, P: 1-6
A visual sense of number

David Burr
John Ross
ResearchOpen Access20 Nov 2007
Nature Precedings

P: 1
Defective DNA repair in Fanconi's anaemia

PETER K. POON
RICHARD L. O'BRIEN
JOHN W. PARKER
Research19 Jul 1974
Nature

Volume: 250, P: 223-225
Characterisation and modelling of potassium-ion batteries

Potassium-ion batteries are a promising alternative to lithium-ion batteries. Here, authors characterise the solid-state diffusivities and exchange current densities of leading negative and positive electrode materials, enabling full-cell modelling to identify the properties limiting rate capability.

Shobhan Dhir
John Cattermull
Mauro Pasta
ResearchOpen Access31 Aug 2024
Nature Communications

Volume: 15, P: 1-12
Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels

cfDNA fragmentomics is a potential clinically applicable method for identifying cancer. Here, the authors assess fragmentomics analysis methods and their application to commercial targeted sequencing panels.

Kyle T. Helzer
Marina N. Sharifi
Shuang G. Zhao
ResearchOpen Access14 Oct 2025
Nature Communications

Volume: 16, P: 1-12
Screening for subtelomeric chromosome abnormalities in children with idiopathic mental retardation using multiprobe telomeric FISH and the new MAPH telomeric assay

Carolina Sismani
John AL Armour
Philippos C Patsalis
Research18 Jul 2001
European Journal of Human Genetics

Volume: 9, P: 527-532
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness

uPAR is a senescence-associated protein, and CAR T cells targeting uPAR exert senolysis. Here Eskiocak et al. identify uPAR⁺ cells as key targets of intestinal aging and show that CAR T-mediated elimination prevents and restores age-related decline in intestinal regeneration and barrier function.

Onur Eskiocak
Joseph Gewolb
Corina Amor
ResearchOpen Access25 Nov 2025
Nature Aging

Volume: 6, P: 108-126
Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) is associated with features of and progression to obstructive lung disease

Spyridon Fortis
Alejandro Comellas
Emily S. Wan
ResearchOpen Access20 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Photoautotrophic hydrogen production by eukaryotic microalgae under aerobic conditions

Eukaryotic algae and cyanobacteria can produce hydrogen in the presence of little or no oxygen. Here, the authors show that two microalgal strains are capable of producing hydrogen under aerobic conditions, and provide new insights into the natural evolution of oxygen-tolerant hydrogenase.

Jae-Hoon Hwang
Hyun-Chul Kim
Byong-Hun Jeon
Research04 Feb 2014
Nature Communications

Volume: 5, P: 1-6
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT_1A receptor

Annick Fargin
John R. Raymond
Robert J. Lefkowitz
Research22 Sept 1988
Nature

Volume: 335, P: 358-360
Photoreactivation and Photoreactivating Enzyme Activity in an Order of Mammals (Marsupialia)

JOHN S. COOK
JAMES D. REGAN
Research06 Sept 1969
Nature

Volume: 223, P: 1066-1067
Antigen distortion allows influenza virus to escape neutralization

Damien Fleury
Steve A. Wharton
Thierry Bizebard
Research01 Feb 1998
Nature Structural Biology

Volume: 5, P: 119-123
Charge migration in supramolecular stacks of peripherally substituted porphyrins

Pieter G. Schouten
John M. Warman
Horng-Long Pan
Research24 Oct 1991
Nature

Volume: 353, P: 736-737
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I

Markus Grompe
Sven Lindstedt
Milton Finegold
Research01 Aug 1995
Nature Genetics

Volume: 10, P: 453-460
Literature for Men of Letters and Science in Russia

L. F. SCHUSTER
Research03 Feb 1921
Nature

Volume: 106, P: 728
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Daniel R. Rosen
Teepu Siddique
Robert H. Brown Jr
Research01 Mar 1993
Nature

Volume: 362, P: 59-62
Application of the Interference Method to the Determination of the Surface Area of Metallic Nickel Films

F. HURN CONSTABLE
Research26 Nov 1927
Nature

Volume: 120, P: 769-770
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
ResearchOpen Access09 Oct 2024
Nature

Volume: 635, P: 462-471
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state

Patriclo T. Huerta
John E. Lisman
Research19 Aug 1993
Nature

Volume: 364, P: 723-725
Protease inhibitors suppress radiation-induced malignant transformation in vitro

ANN R. KENNEDY
JOHN B. LITTLE
Research01 Dec 1978
Nature

Volume: 276, P: 825-826
Perceived geometrical relationships affected by eye-movement signals

Rick H. Cai
Alexandre Pouget
John Schlag
Research10 Apr 1997
Nature

Volume: 386, P: 601-604
Compression of visual space before saccades

John Ross
M. Concetta Morrone
David C. Burr
Research10 Apr 1997
Nature

Volume: 386, P: 598-601
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763
Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings

Polygenic scores derived from genome-wide association analyses of hypertrophic cardiomyopathy and genetically correlated left ventricular traits effectively stratify risk of disease and adverse outcomes in the general population and across clinical cohorts.

Sean L. Zheng
Sean J. Jurgens
James S. Ware
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 563-571
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Pierrick Wainschtein
Deepti Jain
Peter M. Visscher
Research07 Mar 2022
Nature Genetics

Volume: 54, P: 263-273
Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele

Here, the authors leverage whole-genome sequencing from >88,000 diverse individuals to uncover 18 BMI-related genetic signals, including novel variants in participants of African genetic ancestry, highlighting the value of diversity in genetic discovery.

Xinruo Zhang
Jennifer A. Brody
Anne E. Justice
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

Genetic mechanisms of blood pressure regulation remain poorly defined. Here, the authors perform a kidney multi-omics study to identify 399 kidney effector genes, 11 miRNAs and 97 proteins for blood pressure and hypertension.

Xiaoguang Xu
Chachrit Khunsriraksakul
Maciej Tomaszewski
ResearchOpen Access19 Mar 2024
Nature Communications

Volume: 15, P: 1-29
Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

Lois M. Mulligan
John B. J. Kwok
Bruce A. J. Ponder
Research03 Jun 1993
Nature

Volume: 363, P: 458-460
The role of sex steroids in the acquisition and production of birdsong

Peter Marler
Susan Peters
John C. Wingfield
Research29 Dec 1988
Nature

Volume: 336, P: 770-772
Prof. J. T. MacGregor-Morris

W. J. JOHN
Comments & Opinion30 May 1959
Nature

Volume: 183, P: 1497
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
A cell line that can induce thymocyte positive selection

Patrice Hugo
John W. Kappler
Philippa C. Marrack
Research17 Dec 1992
Nature

Volume: 360, P: 679-682
Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

Christian Rosenmund
Daniel W. Carr
Gary L. Westbrook
Research28 Apr 1994
Nature

Volume: 368, P: 853-856
Transparency and the uniqueness constraint in human and computer stereo vision

Stephen B. Pollard
John P. Frisby
Research01 Oct 1990
Nature

Volume: 347, P: 553-556
Impact and importance of a new men’s health strategy in England

The Government’s commitment to a Men’s Health Strategy in England, announced by Wes Streeting, the Secretary of State for Health and Social Care, on 28 November 2024, is a welcome development. The implementation of a strategy will hopefully lead to improved access to services and health outcomes for men and boys.

John Chisholm
Comments & Opinion31 Jan 2025
Nature Reviews Urology

Volume: 22, P: 491-492
Protein Turnover in Tissues of the Rat Fetus following Maternal Starvation

John D Johnson
Tracy Dunham
Robert B Loftfield
Research01 Dec 1986
Pediatric Research

Volume: 20, P: 1252-1257
Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Genome-wide association analyses comprising 14,256 cases and 1,199,156 controls and incorporating correlated cardiac magnetic resonance imaging traits provide insights into the molecular etiology of dilated cardiomyopathy.

Sean L. Zheng
Albert Henry
R. Thomas Lumbers
ResearchOpen Access21 Nov 2024
Nature Genetics

Volume: 56, P: 2646-2658
A complete set of human telomeric probes and their clinical application

Yi Ning
Anna Roschke
William R.A. Brown
Research01 Sept 1996
Nature Genetics

Volume: 14, P: 86-89
Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study

The antibody response to COVID-19 vaccines varies among individuals. Here the authors find that older age, male sex, smoking, higher BMI, vaccine type, and certain comorbidities are associated with lower anti-S1 antibody levels after COVID-19 vaccinations, indicating that certain groups might benefit from higher frequency or doses of vaccination.

John S. Kim
Yifei Sun
Elizabeth C. Oelsner
ResearchOpen Access19 Feb 2024
Nature Communications

Volume: 15, P: 1-12
A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Zilin Li
Xihao Li
Xihong Lin
Research27 Oct 2022
Nature Methods

Volume: 19, P: 1599-1611
Effectiveness evaluation of national nutrition education programmes must be a priority to safeguard nutrition security

Nutrition education and food assistance programmes have the potential to reduce the societal burdens that disproportionately impact those living in low-resource contexts. Here, we call for a standardized evaluation framework, measures and procedures for assessing nutrition education programmes in the USA as critical for achieving nutrition security and population health while lowering the national burden of escalating healthcare costs.

Regan Lucas Bailey
Rebecca Seguin-Fowler
Bart Lynn Fischer
Comments & Opinion23 Apr 2025
Nature Food

Volume: 6, P: 419-422
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Most studies of the genetics of the metabolome have been done in individuals of European descent. Here, the authors integrate genomics and metabolomics in Black individuals, highlighting the value of whole genome sequencing in diverse populations and linking circulating metabolites to human disease.

Usman A. Tahir
Daniel H. Katz
Robert E. Gerszten
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-16
Whole genome sequence analysis of blood lipid levels in >66,000 individuals

Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.

Margaret Sunitha Selvaraj
Xihao Li
Pradeep Natarajan
ResearchOpen Access11 Oct 2022
Nature Communications

Volume: 13, P: 1-18

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