Nature Search

Selective presynaptic inhibition of leg proprioception in behaving Drosophila

A study in Drosophila has identified a neural circuit that selectively suppress movement-encoding proprioceptors during self-generated movements such as walking and grooming.

Chris J. Dallmann
Yichen Luo
John C. Tuthill
Research17 Sept 2025
Nature

Volume: 647, P: 445-453
Synaptic architecture of leg and wing premotor control networks in Drosophila

We use connectomics to compare the wiring logic of premotor circuits controlling the Drosophila leg and wing, finding that both premotor networks cluster into modules that link motor neurons innervating muscles with related functions.

Ellen Lesser
Anthony W. Azevedo
John C. Tuthill
Research26 Jun 2024
Nature

Volume: 631, P: 369-377
Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg

Determining whether somatosensory neurons are involved in internal or external sensing remains a challenge. Here, the authors show that analyzing connectivity is a powerful approach to identify putative neural functions of somatosensory neurons in the fly.

Su-Yee J. Lee
Chris J. Dallmann
Sweta Agrawal
ResearchOpen Access02 May 2025
Nature Communications

Volume: 16, P: 1-16
Connectomic reconstruction of a female Drosophila ventral nerve cord

Automated reconstruction of dense neural networks in the ventral nerve cord of the fruit fly provides a resource for investigating the neural control of movement.

Anthony Azevedo
Ellen Lesser
John C. Tuthill
Research26 Jun 2024
Nature

Volume: 631, P: 360-368
Comparative connectomics of Drosophila descending and ascending neurons

Three electron microscopy datasets are combined to provide a complete connectomic description of the neural circuitry that makes up the neck connective in Drosophila, including the descending neurons, ascending neurons and sensory ascending neurons.

Tomke Stürner
Paul Brooks
Katharina Eichler
ResearchOpen Access30 Apr 2025
Nature

Volume: 643, P: 158-172
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

Vaccines for SARS-COV-2 are needed in the ongoing pandemic. Here the authors characterize a vaccine candidate that presents the receptor-binding domain (RBD) of SARS-CoV-2 spike protein on a synthetic VLP platform using SpyTag/SpyCatcher technology and show immunogenicity of a prime-boost regimen in mice and pigs.

Tiong Kit Tan
Pramila Rijal
Alain R. Townsend
ResearchOpen Access22 Jan 2021
Nature Communications

Volume: 12, P: 1-16
Detection of X-ray emission from a bright long-period radio transient

A long-period radio transient with coincident radio and X-ray emission and observational properties unlike any known Galactic object has been observed by the Australian Square Kilometre Array Pathfinder.

Ziteng Wang
Nanda Rea
Nithyanandan Thyagarajan
Research28 May 2025
Nature

Volume: 642, P: 583-586
Motor neurons generate pose-targeted movements via proprioceptive sculpting

Single motor neurons in Drosophila are stimulated to show that they direct head movements towards specific postures rather than generating fixed movement vectors, suggesting that the brain controls movements through a continuing proprioceptive–motor loop.

Benjamin Gorko
Igor Siwanowicz
Stephen J. Huston
Research20 Mar 2024
Nature

Volume: 628, P: 596-603
Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

A post eradication polio vaccine should be safe and easy to produce. Here, the authors characterize a recombinant virus-like particle polio vaccine with stabilized capsid proteins and show comparable immunogenicity to the current inactivated polio vaccine.

Lee Sherry
Mohammad W. Bahar
David J. Rowlands
ResearchOpen Access18 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

Nathan W Bartlett
Ross P Walton
Sebastian L Johnston
Research03 Feb 2008
Nature Medicine

Volume: 14, P: 199-204
A dusty pinwheel nebula around the massive star WR104

Peter G. Tuthill
John D. Monnier
William C. Danchi
Research08 Apr 1999
Nature

Volume: 398, P: 487-489
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

An effective antiviral against the common cold could prevent exacerbations in asthma and chronic obstructive pulmonary disease, but the diversity and adaptability of the virus makes it a highly challenging target. Now, picomolar inhibitors of a human lipid transferase have been developed. Targeting this human lipid transferase could provide an effective and broad-spectrum approach to block viral replication in the host.

Aurélie Mousnier
Andrew S. Bell
Edward W. Tate
Research14 May 2018
Nature Chemistry

Volume: 10, P: 599-606
A dusty torus around the luminous young star LkHα101

Peter G. Tuthill
John D. Monnier
William C. Danchi
Research22 Feb 2001
Nature

Volume: 409, P: 1012-1014
Images of embedded Jovian planet formation at a wide separation around AB Aurigae

Images from the Subaru Telescope and the Hubble Space Telescope reveal an embedded protoplanet at a wide separation around the star AB Aurigae. The system provides evidence for a long-considered alternative mechanism for forming Jupiter-like planets.

Thayne Currie
Kellen Lawson
Nour Skaf
Research04 Apr 2022
Nature Astronomy

Volume: 6, P: 751-759
Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine

Despite the success of current vaccination against poliomyelitis, safe, cheap and effective vaccines remain sought for continuing eradication effort. Here the authors use plants to express stabilized virus-like particles of type 3 poliovirus that can induce a protective immune response in mice transgenic for the human poliovirus receptor.

Johanna Marsian
Helen Fox
George P. Lomonossoff
ResearchOpen Access15 Aug 2017
Nature Communications

Volume: 8, P: 1-9
The DANNCE of the rats: a new toolkit for 3D tracking of animal behavior

A new approach tracks animal movements in 3D from multiple camera views using volumetric triangulation, reconciling occlusions and ambiguities present in any one camera view.

Pierre Karashchuk
John C. Tuthill
Bingni W. Brunton
News & Views19 Apr 2021
Nature Methods

Volume: 18, P: 460-462
Dense neuronal reconstruction through X-ray holographic nano-tomography

Kuan, Phelps, et al. used synchrotron X-ray imaging and deep learning to map dense neuronal wiring in fly and mouse tissue, enabling examination of individual cells and connectivity in circuits governing motor control and perceptual decision-making.

Aaron T. Kuan
Jasper S. Phelps
Wei-Chung Allen Lee
Research14 Sept 2020
Nature Neuroscience

Volume: 23, P: 1637-1643
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?

Vincent Ting Fung Cheung
Tarun Gupta
Oliver Brain
ResearchOpen Access18 May 2020
British Journal of Cancer

Volume: 123, P: 207-215
Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma

Rajiv M Patel
Erinn Downs-Kelly
Marek Skacel
Research07 Oct 2005
Modern Pathology

Volume: 18, P: 1585-1590
Unusual variants of malignant melanoma

Cynthia M Magro
A Neil Crowson
Martin C Mihm Jr
Research17 Jan 2006
Modern Pathology

Volume: 19, P: S41-S70
Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

Simon P. Graham
Rebecca K. McLean
Teresa Lambe
ResearchOpen Access27 Jul 2020
npj Vaccines

Volume: 5, P: 1-6

Search

Selective presynaptic inhibition of leg proprioception in behaving Drosophila

Synaptic architecture of leg and wing premotor control networks in Drosophila

Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg

Connectomic reconstruction of a female Drosophila ventral nerve cord

Comparative connectomics of Drosophila descending and ascending neurons

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

Detection of X-ray emission from a bright long-period radio transient

Motor neurons generate pose-targeted movements via proprioceptive sculpting

Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

A dusty pinwheel nebula around the massive star WR104

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

A dusty torus around the luminous young star LkHα101

Images of embedded Jovian planet formation at a wide separation around AB Aurigae

Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine

The DANNCE of the rats: a new toolkit for 3D tracking of animal behavior

Dense neuronal reconstruction through X-ray holographic nano-tomography

Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?

Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma

Unusual variants of malignant melanoma

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

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