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Showing 1–12 of 12 results
Advanced filters: Author: John D. MacMicking Clear advanced filters

  • A family of plant guanylate-binding protein-like GTPases controls phase separation and assembly of condensates, thereby forming a circuit that regulates transcriptional responses to biotic stress.

    • Shuai Huang
    • Shiwei Zhu
    • John D. MacMicking
    Research
    Nature
    Volume: 594, P: 424-429

  • Here, John MacMicking provides a broad overview of the recently described functional properties of interferon-inducible effector proteins that mediate cell-autonomous host defence against internalized bacteria, protozoa and viruses.

    • John D. MacMicking
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 367-382

  • Phospholipid scramblase 1 (PLSCR1), a protein induced by IFNγ, acts as a defence factor against SARS-CoV-2 and other coronaviruses by inhibiting the fusion of the virus with host-cell membranes.

    • Dijin Xu
    • Weiqian Jiang
    • John D. MacMicking
    ResearchOpen Access
    Nature
    Volume: 619, P: 819-827

  • One of the body's key defenders against infection—the activated macrophage—engulfs bacteria and destroys them with an acid cocktail inside lysosomes. Mycobacterium tuberculosis seems to have evolved a strategy to cope with this threat (pages 849–854).

    • John D MacMicking
    News & Views
    Nature Medicine
    Volume: 14, P: 809-810

  • How lipopolysaccharide embedded in bacterial membranes is sensed by intracellular defense mechanisms has been puzzling. Randow and colleagues show that guanylate-binding proteins assemble on the surface of Gram-negative bacteria to initiate downstream pyroptosis.

    • Michal P. Wandel
    • Bae-Hoon Kim
    • Felix Randow
    Research
    Nature Immunology
    Volume: 21, P: 880-891

  • Suppression of salicylic acid production in Arabidopsis thaliana at high temperature is caused by decreased recruitment of GUANYLATE BINDING PROTEIN-LIKE 3 defence-associated condensates on promoter sites of master immune regulatory genes.

    • Jong Hum Kim
    • Christian Danve M. Castroverde
    • Sheng Yang He
    ResearchOpen Access
    Nature
    Volume: 607, P: 339-344

  • Infection with Shigella flexneri bacteria is a major cause of infant death. It emerges that S. flexneri evades intracellular defences by releasing a protein that triggers the destruction of members of a key family of host enzymes. See Letter p.378

    • John D. MacMicking
    News & Views
    Nature
    Volume: 551, P: 303-304

  • Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF4 is essential for the down-regulation of NOD2 signalling.

    • Pradeep Bist
    • Wan Shoo Cheong
    • Bindu Sukumaran
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16