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Showing 1–18 of 18 results
Advanced filters: Author: John Maraganore Clear advanced filters
  • A selection of individuals from the biotech ecosystem give their views on the challenges facing the sector over the coming years.

    • Anu Acharya
    • Kate Bingham
    • Daphne Zohar
    Special Features
    Nature Biotechnology
    Volume: 34, P: 276-283
  • RNA interference (RNAi) has rapidly advanced since its initial discovery to form the basis of a new class of therapeutics. De Fougerolles and colleagues discuss the challenges in the development of RNAi-based therapeutics, focusing on lead identification/optimization and effective delivery, and review the latest clinical results.

    • Antonin de Fougerolles
    • Hans-Peter Vornlocher
    • Judy Lieberman
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 443-453
  • Recollections from an extraordinary 19-year journey guiding a tiny startup with an unproven therapeutic modality into a mature drug company with marketed products and >1,600 employees in nearly 20 countries provide lessons for those seeking to create the culture and values that are core to biotech success.

    • John Maraganore
    Comments & Opinion
    Nature Biotechnology
    Volume: 40, P: 641-650
  • Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process, sponsored by the Human Genome Epidemiology Network. A workshop is planned to develop consensus guidelines for reporting results of genetic association studies. Published literature databases will be integrated, and unpublished data, including 'negative' studies, will be captured by online journals and through investigator networks. Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews.

    • John P A Ioannidis
    • Marta Gwinn
    • Muin J Khoury
    Comments & Opinion
    Nature Genetics
    Volume: 38, P: 3-5
  • Recent work found that overexpression of short hairpin RNAs in cells could lead to mortality in mice, this was attributed to interference with the cellular machinery that makes miRNAs. This raised the issue of whether RNA interference-mediated silencing would be therapeutically possible. This paper shows that small interfering RNAs can be systemically administered and effectively suppress gene expression without compromising the activity of various liver miRNAs.

    • Matthias John
    • Rainer Constien
    • David Bumcrot
    Research
    Nature
    Volume: 449, P: 745-747
  • Systemically administered modified siRNAs can be used in monkeys to achieve long-lasting silencing of a gene — previously, this had been established only in mice.

    • Tracy S. Zimmermann
    • Amy C. H. Lee
    • Ian MacLachlan
    Research
    Nature
    Volume: 441, P: 111-114