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Showing 1–8 of 8 results
Advanced filters: Author: Joleen Masschelein Clear advanced filters

  • Enacyloxin IIa is an antibiotic, assembled by a modular polyketide synthase, with promising activity against the Gram-negative bacterium Acinetobacter baumannii. Now, it has been shown that the enacyloxin IIa polyketide chain is released via transfer to a separately encoded carrier protein by a non-elongating ketosynthase domain, followed by condensation with 3,4-dihydroxycyclohexane carboxylic acid by a non-ribosomal peptide synthetase condensation domain.

    • Joleen Masschelein
    • Paulina K. Sydor
    • Gregory L. Challis
    Research
    Nature Chemistry
    Volume: 11, P: 906-912

  • The antibiotic enacyloxin IIa is assembled by a modular polyketide synthase, and released from it by condensation of the enacyloxin acyl chain with 3,4-dihydroxycyclohexane carboxylic acid. A multipronged approach shows the structural basis for recognition between the peptidyl carrier protein domain that bears the acyl chain and the non-ribosomal peptide synthetase condensation domain that ligates it with the carboxylic acid.

    • Simone Kosol
    • Angelo Gallo
    • Józef R. Lewandowski
    Research
    Nature Chemistry
    Volume: 11, P: 913-923

  • Microbial synthetic biology might greatly benefit from the application of non-model organisms, which have been evolutionarily optimized for the production of specific proteins and metabolites. This Review discusses the design and application of endogenous production in non-model organisms.

    • Jorien Poppeliers
    • Maarten Boon
    • Rob Lavigne
    Reviews
    Nature Reviews Bioengineering
    Volume: 4, P: 67-81

  • Polyketide synthases infrequently insert β-branched monomers into their growing polyketide chains, the details of which are not well established. Bioinformatic, structural and mutational analyses now define a core motif and surface residues in acyl carrier proteins that govern insertion of β-branched units.

    • Anthony S Haines
    • Xu Dong
    • Matthew P Crump
    Research
    Nature Chemical Biology
    Volume: 9, P: 685-692

  • Advances in computational omics technologies are enabling access to the hidden diversity of natural products, and artificial intelligence approaches are facilitating key steps in harnessing the therapeutic potential of such compounds, including biological activity prediction. This article discusses synergies between these fields to effectively identify drug candidates from the plethora of molecules produced by nature, and how to address the challenges in realizing the potential of these synergies.

    • Michael W. Mullowney
    • Katherine R. Duncan
    • Marnix H. Medema
    Reviews
    Nature Reviews Drug Discovery
    Volume: 22, P: 895-916

  • A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

    • Marnix H Medema
    • Renzo Kottmann
    • Frank Oliver Glöckner
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 11, P: 625-631