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Showing 1–4 of 4 results

Advanced filters: Author: Jon Koff Clear advanced filters

Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis

A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of antimicrobial-resistant bacterial infections.

Benjamin K. Chan
Gail L. Stanley
Jonathan L. Koff
ResearchOpen Access29 Apr 2025
Nature Medicine

Volume: 31, P: 1494-1501
Phage therapy with nebulized cocktail BX004-A for chronic Pseudomonas aeruginosa infections in cystic fibrosis: a randomized first-in-human trial

In a randomized, placebo-controlled trial, an inhaled phage cocktail was well tolerated in adults with cystic fibrosis and chronic Pseudomonas aeruginosa infection, with evidence of lung delivery and signs of bacterial reduction.

Iddo Weiner
Maya Kahan-Hanum
Merav Bassan
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University

Silvia Würstle
Alina Lee
Benjamin K. Chan
ResearchOpen Access01 Feb 2024
Scientific Reports

Volume: 14, P: 1-13
Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium

A Kalinowski
B T Galen
J L Koff
Research07 Feb 2018
Mucosal Immunology

Volume: 11, P: 958-967