A DNA-encoded reaction discovery system has revealed reactivity that led to the development of a visible-light-induced, biomolecule-compatible azide reduction. This reaction exhibits remarkable chemoselectivity and can be performed on oligonucleotide and oligosaccharide substrates, and in the presence of a protein enzyme, without undesired side reactions or loss of enzyme activity.
- Yiyun Chen
- Adam S. Kamlet
- David R. Liu
