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Your brain on drugs

Manipulation of stem cells is an important therapeutic goal that has proven difficult to achieve. A recent report describes a novel in vivo small-molecule screen and identifies a modulator of mammalian neurogenesis that partially reverses age-related declines in cognition.

Jonathan P Saxe
News & Views01 Sept 2010
Nature Chemical Biology

Volume: 6, P: 639-640
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

Infant gliomas behave differently to their childhood or adult counterparts. Here, the authors perform a large-scale genetic analysis of these tumours, revealing genetic alterations which may offer therapeutic opportunities.

Ana S. Guerreiro Stucklin
Scott Ryall
Cynthia Hawkins
ResearchOpen Access25 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Parity and lactation induce T-cell-mediated breast cancer protection

Parity induces an accumulation of CD8⁺ T cells, including cells with a tissue-resident-memory-like phenotype within human normal breast tissue, offering long-term protection against triple-negative breast cancer.

Balaji Virassamy
Franco Caramia
Sherene Loi
ResearchOpen Access20 Oct 2025
Nature

Volume: 649, P: 449-459
Wild-type microglia arrest pathology in a mouse model of Rett syndrome

Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.

Noël C. Derecki
James C. Cronk
Jonathan Kipnis
Research18 Mar 2012
Nature

Volume: 484, P: 105-109
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Seronegative healthcare workers with an innate signature of infection preferentially expand pre-existing T cells targeting the conserved replication transcription complex of SARS-CoV-2 in abortive infection.

Leo Swadling
Mariana O. Diniz
Mala K. Maini
ResearchOpen Access10 Nov 2021
Nature

Volume: 601, P: 110-117
The binary protein-protein interaction landscape of Escherichia coli

Yeast-two hybrid screening of E. coli proteins and integration with protein structure and genetic interaction data provides an extensive interactome resource.

Seesandra V Rajagopala
Patricia Sikorski
Peter Uetz
Research23 Feb 2014
Nature Biotechnology

Volume: 32, P: 285-290
Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post-traumatic stress

Charlotte C. Bavley
Zeeba D. Kabir
Anjali M. Rajadhyaksha
Research24 Apr 2020
Molecular Psychiatry

Volume: 26, P: 2286-2298
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson
Sarah Maguire
Olivia Fletcher
ResearchOpen Access26 Jan 2021
British Journal of Cancer

Volume: 124, P: 842-854
Direct-write of free-form building blocks for artificial magnetic 3D lattices

Lukas Keller
Mohanad K. I. Al Mamoori
Michael Huth
ResearchOpen Access18 Apr 2018
Scientific Reports

Volume: 8, P: 1-13
Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J. McCabe
Marie-Emilie A. Gauthier
Mary-Anne Young
ResearchOpen Access19 Nov 2019
Scientific Reports

Volume: 9, P: 1-16
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14

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Your brain on drugs

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

Parity and lactation induce T-cell-mediated breast cancer protection

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

The binary protein-protein interaction landscape of Escherichia coli

Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post-traumatic stress

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

CYP3A71C* allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Direct-write of free-form building blocks for artificial magnetic 3D lattices

Development and validation of a targeted gene sequencing panel for application to disparate cancers

FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

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