Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–23 of 23 results
Advanced filters: Author: Jorge A. Marchand Clear advanced filters

  • Riboswitches are allosteric RNA molecules that change conformation upon ligand binding to regulate downstream genes. Here, the authors use Restricted Boltzmann machines trained on natural sequences to design new riboswitch aptamer domains, and validate their functionality via chemical probing.

    • Jorge Fernandez-de-Cossio-Diaz
    • Pierre Hardouin
    • Simona Cocco
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Alkynes found in natural products are typically assembled by metal-dependent enzymes. The enzyme BesB instead forms a terminal alkyne-containing amino acid using pyridoxal phosphate as a cofactor. Here, the authors use structural and mechanistic investigations to identify the key features of BesB that allow it to carry out its fascinating chemistry.

    • Jason B. Hedges
    • Jorge A. Marchand
    • Katherine S. Ryan
    Research
    Nature Chemical Biology
    Volume: 22, P: 77-86

  • Binding-activated optical sensors are powerful tools, but their development can be slow and laborious. Here, authors introduce a platform to expedite biosensor discovery and evolution using genetically encodable fluorogenic amino acids.

    • Erkin Kuru
    • Jonathan Rittichier
    • George M. Church
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Unnatural base pairing xenonucleic acids (XNAs) can be used to expand life’s alphabet beyond ATGC. Here, authors show strategies for enzymatic synthesis and next-generation nanopore sequencing of XNA base pairs for reading and writing 12-letter DNA (ATGCBSPZXKJV).

    • Hinako Kawabe
    • Christopher A. Thomas
    • Jorge A. Marchand
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Structural characterization of the amino-acid-modifying radical halogenase BesD and identification of new members of this protein family provides insight into the enzymatic mechanism and enables biocatalytic production of halogenated amino acids.

    • Monica E. Neugebauer
    • Kiera H. Sumida
    • Michelle C. Y. Chang
    Research
    Nature Chemical Biology
    Volume: 15, P: 1009-1016

  • A study details the creation of an Escherichia coli genetically recoded organism that is resistant to viral infection, and describes a further modification that keeps the organism and its genetic information biocontained.

    • Akos Nyerges
    • Svenja Vinke
    • George M. Church
    Research
    Nature
    Volume: 615, P: 720-727

  • Genome-wide association studies (GWAS) have revealed gene variants associated with breast cancer, but their association with breast cancer development in Latinas is not clear. Here, the authors carry out a GWAS of breast cancer in Latinas and identify a significant protective variant of Indigenous American origin in the 6q25 region.

    • Laura Fejerman
    • Nasim Ahmadiyeh
    • Elad Ziv
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-8

  • The authors pooled resources to identify best practices and develop a new standardized protocol for estimating functional connectivity in rats with magnetic resonance imaging.

    • Joanes Grandjean
    • Gabriel Desrosiers-Gregoire
    • Andreas Hess
    Research
    Nature Neuroscience
    Volume: 26, P: 673-681

  • The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.

    • Michael R. Bowl
    • Michelle M. Simon
    • Steve D. M. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.

    • Natasha A. Karp
    • Jeremy Mason
    • Jacqueline K. White
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

    • G. Aad
    • B. Abbott
    • L. Zwalinski
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-14

  • A study from the FANTOM consortium using single-molecule cDNA sequencing of transcription start sites and their usage in human and mouse primary cells, cell lines and tissues reveals insights into the specificity and diversity of transcription patterns across different mammalian cell types.

    • Alistair R. R. Forrest
    • Hideya Kawaji
    • Yoshihide Hayashizaki
    Research
    Nature
    Volume: 507, P: 462-470

  • Montserrat Garcia-Closas and colleagues report a meta-analysis of three genome-wide association studies for estrogen receptor (ER)-negative breast cancer, including 4,193 ER-negative breast cancer cases and 35,194 controls, with replication using the iCOGS custom genotyping array in 40 studies, including 6,514 cases and 41,455 controls. They identify four loci associated with ER-negative but not ER-positive breast cancer.

    • Montserrat Garcia-Closas
    • Fergus J Couch
    • Peter Kraft
    Research
    Nature Genetics
    Volume: 45, P: 392-398

  • Keri Monda, Kari North, Christopher Haiman and colleagues report a meta-analysis of GWAS for body mass index that is composed of 39,144 individuals of African ancestry, followed by further genotyping in 32,268 individuals of African ancestry. The study also includes analysis of publicly available data from the GIANT consortium of ~124,000 individuals of European ancestry. The paper reports evidence for two new loci near GALNT10 and MIR148A.

    • Keri L Monda
    • Gary K Chen
    • Christopher A Haiman
    Research
    Nature Genetics
    Volume: 45, P: 690-696

  • Christopher Haiman and colleagues report a genome-wide association study for estrogen receptor (ER)-negative breast cancer in women of African and European ancestry. They identify a variant at the TERT-CLPTM1L locus on 5p15 as associated with ER-negative and triple-negative breast cancer. This locus also harbors multiple variants associated with a range of other cancers.

    • Christopher A Haiman
    • Gary K Chen
    • Fergus J Couch
    Research
    Nature Genetics
    Volume: 43, P: 1210-1214

  • The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

    • Marie-Christine Birling
    • Atsushi Yoshiki
    • Stephen A. Murray
    Comments & Opinion
    Nature Genetics
    Volume: 53, P: 416-419