Cardiac tissue remodeling in heart failure is driven by interactions between multiple cell types, but existing studies have not fully captured these coordinated responses. Here, the authors show that integrating bulk and single-cell transcriptomics across 1,524 individuals reveals robust multicellular programs that link fibroblast activation to cardiomyocyte stress and recovery.
- Jan D. Lanzer
- Ricardo O. Ramirez Flores
- Julio Saez-Rodriguez
