Nature Search

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
APEX1, a transcriptional hub for endochondral ossification and fracture repair

José Valdés-Fernández
Miguel Echanove-González de Anleo
Froilán Granero-Moltó
ResearchOpen Access16 Jan 2026
Bone Research

Volume: 14, P: 1-16
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial

Exercise modulates brown adipose tissue (BAT) metabolism in murine models. Here the authors report that there is no evidence that 24 weeks of supervised exercise training modulates BAT volume or function in young sedentary adults in the ACTIBATE randomized controlled trial.

Borja Martinez-Tellez
Guillermo Sanchez-Delgado
Jonatan R. Ruiz
ResearchOpen Access12 Sept 2022
Nature Communications

Volume: 13, P: 1-12
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Chiea Chuen Khor, Tin Aung and colleagues report the results of a large genome-wide association study of primary angle closure glaucoma. They identify five new susceptibility loci and provide insights into disease pathogenesis.

Chiea Chuen Khor
Tan Do
Tin Aung
Research04 Apr 2016
Nature Genetics

Volume: 48, P: 556-562
Co-limitation towards lower latitudes shapes global forest diversity gradients

Examining drivers of the latitudinal biodiversity gradient in a global database of local tree species richness, the authors show that co-limitation by multiple environmental and anthropogenic factors causes steeper increases in richness with latitude in tropical versus temperate and boreal zones.

Jingjing Liang
Javier G. P. Gamarra
Cang Hui
Research08 Aug 2022
Nature Ecology & Evolution

Volume: 6, P: 1423-1437
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Notch and interacting signalling pathways in cardiac development, disease, and regeneration

In this Review, de la Pompa and colleagues describe the role of the Notch pathway during the differentiation and patterning of cardiac tissues and in valve and ventricular chamber development, discussing the crosstalk with other signalling pathways, how defective Notch signalling is linked to congenital heart diseases, and the relevance of the Notch pathway in heart regeneration and repair.

Donal MacGrogan
Juliane Münch
José Luis de la Pompa
Reviews04 Oct 2018
Nature Reviews Cardiology

Volume: 15, P: 685-704
The global distribution and drivers of wood density and their impact on forest carbon stocks

Wood density is an important plant trait. Data from 1.1 million forest inventory plots and 10,703 tree species show a latitudinal gradient in wood density, with temperature and soil moisture explaining variation at the global scale and disturbance also having a role at the local level.

Lidong Mo
Thomas W. Crowther
Constantin M. Zohner
ResearchOpen Access15 Oct 2024
Nature Ecology & Evolution

Volume: 8, P: 2195-2212
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy

The Notch signaling pathway has a key role in shaping the developing heart. Guillermo Luxán et al. identify two human mutations in the gene encoding the Notch pathway protein MIB1 that cause a type of cardiomyopathy, left ventricular noncompaction. The authors show that mice lacking Mib1 in the myocardium have a similar type of cardiomyopathy and analyze how MIB1 deficiency leads to defective ventricular development.

Guillermo Luxán
Jesús C Casanova
José Luis de la Pompa
Research13 Jan 2013
Nature Medicine

Volume: 19, P: 193-201
Integrated global assessment of the natural forest carbon potential

Analysis of ground-sourced and satellite-derived models reveals a global forest carbon potential of 226 Gt outside agricultural and urban lands, with a difference of only 12% across these modelling approaches.

Lidong Mo
Constantin M. Zohner
Thomas W. Crowther
ResearchOpen Access13 Nov 2023
Nature

Volume: 624, P: 92-101
Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes

The transport of bicarbonate anions across cell membranes by proteins is an important biological process, and if not regulated properly it can lead to cystic fibrosis and heart disease. Now, it has been shown that ‘small’ molecules can also promote efficient bicarbonate transport across lipid membranes and could be used to probe this process.

Jeffery T. Davis
Philip A. Gale
Roberto Quesada
Research19 Apr 2009
Nature Chemistry

Volume: 1, P: 138-144
Structure of melanins from the fungi Ochroconis lascauxensis and Ochroconis anomala contaminating rock art in the Lascaux Cave

José Maria De la Rosa
Pedro M. Martin-Sanchez
Cesareo Saiz-Jimenez
ResearchOpen Access18 Oct 2017
Scientific Reports

Volume: 7, P: 1-11
Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

Genetic and Structural analysis of COVID patients cohort reveals a correlation between mitochondrial haplogroup and SARS-CoV-2 severity.

José Luis Cabrera-Alarcon
Raquel Cruz
José Antonio Enriquez
ResearchOpen Access09 Jan 2025
Communications Biology

Volume: 8, P: 1-12
Partial asynchrony of coniferous forest carbon sources and sinks at the intra-annual time scale

Forest carbon source and sink processes may have contrasting climatic sensitivities. This analysis on 177 coniferous forest sites shows that carbon fluxes and wood formation are coupled but not fully synchronous at intra-annual scales, with peaks in cambial activity preceding those in photosynthesis and respiration.

Roberto Silvestro
Maurizio Mencuccini
Sergio Rossi
ResearchOpen Access05 Aug 2024
Nature Communications

Volume: 15, P: 1-12
Positive feedbacks and alternative stable states in forest leaf types

Alternative stable states in forests have implications for the biosphere. Here, the authors combine forest biodiversity observations and simulations revealing that leaf types across temperate regions of the NH follow a bimodal distribution suggesting signatures of alternative forest states.

Yibiao Zou
Constantin M. Zohner
Thomas W. Crowther
ResearchOpen Access31 May 2024
Nature Communications

Volume: 15, P: 1-15
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1

Mutations in BRCA1 are associated with an increased risk of breast and ovarian cancer. Here the authors show that EDC4, a component of P-bodies, is a member of the BRCA1 complex with roles in stimulating end resection at breaks.

Gonzalo Hernández
María José Ramírez
Jordi Surrallés
ResearchOpen Access06 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Specific driving of the suicide E gene by the CEA promoter enhances the effects of paclitaxel in lung cancer

Ana Rosa Rama Ballesteros
Rosa Hernández
Jose Prados
Research24 Sept 2019
Cancer Gene Therapy

Volume: 27, P: 657-668
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality.

Luis A. Pérez-Jurado
Alejandro Cáceres
Juan R. González
ResearchOpen Access19 Feb 2024
Communications Biology

Volume: 7, P: 1-14
Whole-Exome Sequencing of Congenital Glaucoma Patients Reveals Hypermorphic Variants in GPATCH3, a New Gene Involved in Ocular and Craniofacial Development

Jesús-José Ferre-Fernández
José-Daniel Aroca-Aguilar
Julio Escribano
ResearchOpen Access11 Apr 2017
Scientific Reports

Volume: 7, P: 1-18
Tripalmitin nanoparticle formulations significantly enhance paclitaxel antitumor activity against breast and lung cancer cells in vitro

María Carmen Leiva
Raúl Ortiz
Jose Prados
ResearchOpen Access18 Oct 2017
Scientific Reports

Volume: 7, P: 1-15
Five-year trajectories of multimorbidity patterns in an elderly Mediterranean population using Hidden Markov Models

Concepción Violán
Sergio Fernández-Bertolín
Margarita Cabrera-Bean
ResearchOpen Access09 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
The global biogeography of tree leaf form and habit

Integrating inventory data with machine learning models reveals the global composition of tree types—needle-leaved evergreen individuals dominate, followed by broadleaved evergreen and deciduous trees—and climate change risks.

Haozhi Ma
Thomas W. Crowther
Constantin M. Zohner
ResearchOpen Access23 Oct 2023
Nature Plants

Volume: 9, P: 1795-1809
The redox metabolic pathways function to limit Anaplasma phagocytophilum infection and multiplication while preserving fitness in tick vector cells

Pilar Alberdi
Alejandro Cabezas-Cruz
José de la Fuente
ResearchOpen Access13 Sept 2019
Scientific Reports

Volume: 9, P: 1-15
Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer

Ariadna Martín-Blázquez
Caridad Díaz
José Pérez del Palacio
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group

Claudia Sargas
Rosa Ayala
Esther Prados de la Torre
ResearchOpen Access12 May 2023
Blood Cancer Journal

Volume: 13, P: 1-7
Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort

Jonás Carmona-Pírez
Beatriz Poblador-Plou
Alexandra Prados-Torres
ResearchOpen Access26 Feb 2021
Scientific Reports

Volume: 11, P: 1-9
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

Simon Stacey, Kari Stefansson and colleagues show that a germline variant in the TP53 polyadenylation signal is associated with increased risk of basal cell carcinoma and other solid tumors.

Simon N Stacey
Patrick Sulem
Kari Stefansson
Research25 Sept 2011
Nature Genetics

Volume: 43, P: 1098-1103
Kinetic study, byproducts characterization and photodegradation pathway of profoxydim in a biochar water soil system

Álvaro Cervantes-Díaz
Juan Carlos Nieto-Carmona
Pilar Sandín-España
ResearchOpen Access07 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Metabolomic profiling of COVID-19 using serum and urine samples in intensive care and medical ward cohorts

Ana Isabel Tristán
Cristina Jiménez-Luna
Ignacio Fernández
ResearchOpen Access10 Oct 2024
Scientific Reports

Volume: 14, P: 1-14
Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity

Belén Prados
Paula Gómez-Apiñániz
José Luis de la Pompa
ResearchOpen Access14 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-15
Digestive and appendicular soft-parts, with behavioural implications, in a large Ordovician trilobite from the Fezouata Lagerstätte, Morocco

Juan C. Gutiérrez-Marco
Diego C. García-Bellido
Artur A. Sá
ResearchOpen Access10 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
Anaplasma phagocytophilum modifies tick cell microRNA expression and upregulates isc-mir-79 to facilitate infection by targeting the Roundabout protein 2 pathway

Sara Artigas-Jerónimo
Pilar Alberdi
José de la Fuente
ResearchOpen Access24 Jun 2019
Scientific Reports

Volume: 9, P: 1-15
A synthetic data generation system for myalgic encephalomyelitis/chronic fatigue syndrome questionnaires

Marcos Lacasa
Ferran Prados
Jordi Casas-Roma
ResearchOpen Access31 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
Correction: Specific driving of the suicide E gene by the CEA promoter enhances the effects of paclitaxel in lung cancer

Ana Rosa Rama Ballesteros
Rosa Hernández
Jose Prados
Amendments and Corrections06 Feb 2020
Cancer Gene Therapy

Volume: 27, P: 513
Stereological study of organelle distribution in human mature oocytes

Tânia Santos
Ana S. Pires-Luís
Mário Sousa
ResearchOpen Access28 Oct 2024
Scientific Reports

Volume: 14, P: 1-11
Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages

Belén Prados
Raquel del Toro
José Luis de la Pompa
ResearchOpen Access22 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-12
The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis

Miguel Angel Pascual-Itoiz
Ainize Peña-Cearra
Leticia Abecia
ResearchOpen Access17 Jan 2020
Scientific Reports

Volume: 10, P: 1-13
CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism

Sonia García-Rodríguez
Antonio Rosal-Vela
Jaime Sancho
ResearchOpen Access20 Feb 2018
Scientific Reports

Volume: 8, P: 1-19
Gender specific differences in oxidative stress and inflammatory signaling in healthy term neonates and their mothers

Javier Diaz-Castro
Mario Pulido-Moran
Julio J. Ochoa
Research24 May 2016
Pediatric Research

Volume: 80, P: 595-601
A global assemblage of regional prescribed burn records — GlobalRx

Alice Hsu
Matthew W. Jones
Emma Zerr
ResearchOpen Access01 Jul 2025
Scientific Data

Volume: 12, P: 1-30
Perceived stress modulates the activity between the amygdala and the cortex

Inês Caetano
Sónia Ferreira
Nuno Sousa
Research18 Sept 2022
Molecular Psychiatry

Volume: 27, P: 4939-4947
A spatial stream-network approach assists in managing the remnant genetic diversity of riparian forests

Patricia María Rodríguez-González
Cristina García
Maria Helena Almeida
ResearchOpen Access01 May 2019
Scientific Reports

Volume: 9, P: 1-10

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