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Enabling global-scale nucleic acid repositories through versatile, scalable biochemical selection from room-temperature archives

Large biospecimen banks are limited by a lack of fast, flexible, database-like retrieval. Here, authors encode metadata as DNA barcodes on silica-encapsulated samples and demonstrate numerical range, categorical, and Boolean queries, enabling rapid, precise recall from pooled DNA/RNA archives.

Joseph D. Berleant
James L. Banal
Mark Bathe
ResearchOpen Access14 Feb 2026
Nature Communications

P: 1-15
Random access DNA memory using Boolean search in an archival file storage system

Silica beads encapsulating DNA information and functionalized with DNA labels create an alternative DNA data storage system, where direct random access and data retrieval are enabled by complementary fluorescent strands that identify beads for separation in fluorescence-activated sorting.

James L. Banal
Tyson R. Shepherd
Mark Bathe
Research10 Jun 2021
Nature Materials

Volume: 20, P: 1272-1280
Compiler-aided systematic construction of large-scale DNA strand displacement circuits using unpurified components

DNA circuits hold promise for advancing information-based molecular technologies, yet it is challenging to design and construct them in practice. Thubagereet al. build DNA strand displacement circuits using unpurified strands whose sequences are automatically generated from a user-friendly compiler.

Anupama J. Thubagere
Chris Thachuk
Lulu Qian
ResearchOpen Access23 Feb 2017
Nature Communications

Volume: 8, P: 1-12

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Enabling global-scale nucleic acid repositories through versatile, scalable biochemical selection from room-temperature archives

Random access DNA memory using Boolean search in an archival file storage system

Compiler-aided systematic construction of large-scale DNA strand displacement circuits using unpurified components

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